Examining the link between urine proteins and urinary symptoms in men with prostate enlargement
The Association of Urinary BDNF and NGF With Lower Urinary System Parameters in Patients With Bladder Outlet Obstruction Secondary to Benign Prostate Hyperplasia
NA · Marmara University · NCT06265519
This study is testing how certain proteins in urine relate to urinary problems in older men with prostate enlargement and whether a specific surgery can help improve their symptoms.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | Male |
| Sponsor | Marmara University (other) |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT06265519 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between urine levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) with lower urinary system parameters in men suffering from benign prostatic hyperplasia (BPH) and associated bladder outlet obstruction. It aims to understand how these proteins correlate with symptoms such as increased urination frequency and difficulty in urination. The intervention involves holmium laser enucleation of the prostate to alleviate symptoms and assess changes in urinary parameters post-procedure. The study focuses on older men, as BPH is a prevalent condition in this demographic.
Who should consider this trial
Good fit: Ideal candidates are men aged 50-80 with bladder outlet obstruction due to benign prostatic hyperplasia.
Not a fit: Patients with known neurological diseases, diabetes, urinary tract infections, or those who have had previous prostate surgery will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of urinary symptoms in men with BPH.
How similar studies have performed: While studies have explored urinary biomarkers in relation to BPH, this specific approach focusing on BDNF and NGF in conjunction with surgical intervention is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 50-80 years Male 2. Patients with bladder outlet obstruction secondary to benign prostate hyperplasia Exclusion Criteria: 1. Known neurological disease 2. Diabetes 3. Urinary tract infection 4. Previous prostate surgery 5. Spinal Cord Trauma 7-Bladder stone 8-Cerebrovascular disease 9-Chronic Renal Failure 10-Ureteral stenosis
Where this trial is running
Istanbul
- Marmara University Hospital — Istanbul, Turkey (Türkiye) (RECRUITING)
Study contacts
- Study coordinator: Haydar Kamil ÇAM, Prof. Dr.
- Email: kamilcam@hotmail.com
- Phone: +905323259547
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Benign Prostatic Hyperplasia With Outflow Obstruction, Lower Urinary Tract Obstructive Syndrome