Examining the link between ultrasound grading and kidney injury in ICU patients
The Association Between Venous Excess Ultrasound, the Lung Ultrasound Score and Acute Kidney Injury and Death in the Intensive Care Unit Population
This study is trying to see if a special ultrasound method can help doctors identify ICU patients at risk of kidney injury from too much fluid.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 136 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT06585722 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between the venous excess ultrasound grading system (VExUS) and important patient outcomes, including acute kidney injury, mortality, and length of stay in ICU patients. By assessing fluid overload through VExUS, the study seeks to identify patients who may be at risk from excessive fluid administration. Additionally, a secondary analysis will investigate the correlation between VExUS and lung ultrasound scores. The findings could provide valuable insights into managing fluid therapy in critically ill patients.
Who should consider this trial
Good fit: Ideal candidates for this study are ICU patients aged 18 years or older who are expected to remain in the ICU for more than 24 hours.
Not a fit: Patients with specific medical histories, such as major cardiac shunts or those who have undergone kidney or liver transplants, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the management of fluid therapy in ICU patients, potentially reducing the incidence of acute kidney injury and improving overall outcomes.
How similar studies have performed: While the use of ultrasound in assessing fluid status is gaining traction, the specific application of VExUS in relation to patient outcomes in the ICU is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * all patients admitted to the ICU 18 years or older expected to stay in the ICU for more than 24 hours Exclusion Criteria: * any obstruction between the righ atrium and structures assessed by VExUS * a medical history of: Major cardiac shunts (e.g. atrial septum defect), Tricuspid regurgitation, dialysis, portal hypertension, pulmonary hypertension, interstitial lung disease, recipients of a kidney of liver transplant. * patients in whom an ultrasound assesment is unfeasible e.g. a BMI over 40
Where this trial is running
Amsterdam, North Holland
- Amsterdam UMC — Amsterdam, North Holland, Netherlands (Recruiting)
Study contacts
- Study coordinator: Pieter R Tuinman, PhD
- Email: p.tuinman@amsterdamumc.nl
- Phone: 0204444444
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.