Examining the link between radiological lesions and vestibular function in patients with bilateral vestibulopathy
Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
This study is trying to see if there's a connection between brain scans and balance problems in people with bilateral vestibulopathy, including those with a specific genetic mutation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Jessa Hospital Academic / other |
| Locations | 1 site (Hasselt, Limburg) |
| Trial ID | NCT04070937 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the correlation between radiological lesions detected through CT and MR imaging of the temporal bone and vestibular function in patients diagnosed with bilateral vestibulopathy. Participants will undergo various vestibular tests, including video head impulse tests and caloric response assessments, to evaluate their vestibular function according to the Barany criteria. The study will also compare findings from patients with the p.P51S mutation in COCH to those with non-genetic vestibular impairment. The goal is to enhance understanding of the relationship between radiological findings and vestibular deficits.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who meet the Barany criteria for bilateral vestibulopathy.
Not a fit: Patients under 18 years old or those who do not meet the Barany criteria for bilateral vestibulopathy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve diagnostic accuracy and treatment strategies for patients with bilateral vestibulopathy.
How similar studies have performed: While there have been studies examining vestibular function and imaging, this specific correlation in bilateral vestibulopathy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain \<0.6, measured by the video-HIT5 or scleral-coil technique and/or * reduced caloric response6 (sum of bither- mal max. peak SPV on each side \<6◦/sec7) and/or * reduced horizontal angular VOR gain \<0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ /sec) and a phase lead \>68 degrees (time constant \<5 sec). * must be 18 or older Exclusion Criteria: * \< 18 y * does not meet Barany criteria for BV * contraindication for CT and MR imaging
Where this trial is running
Hasselt, Limburg
- Jessa Hospital — Hasselt, Limburg, Belgium (Recruiting)
Study contacts
- Study coordinator: sebastien p JanssensdeVarebeke, MD
- Email: drsjanssens@gmail.com
- Phone: 011337420
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.