Examining the link between NOAC levels and health outcomes in atrial fibrillation patients
The Association Between Non-vitamin K Antagonist Oral Anticoagulant Concentration and Clinical Outcomes (The Direct Oral AntiCoagulant Registry in Taiwan, DOACT)
This study looks at how the levels of a specific blood thinner in patients with atrial fibrillation affect their health, including risks of stroke and bleeding.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 2 sites (Taipei, Please Select and 1 other locations) |
| Trial ID | NCT05333666 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between the concentration of non-vitamin K antagonist oral anticoagulants (NOAC) and clinical outcomes in patients with atrial fibrillation. The research team has enrolled patients receiving NOAC therapy at National Taiwan University Hospital and will analyze their NOAC levels alongside various clinical outcomes such as ischemic stroke and major bleeding. By examining factors that influence NOAC concentration, the study aims to enhance understanding of how these levels correlate with patient health outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 20 years old who are currently undergoing NOAC therapy.
Not a fit: Patients who are unable to provide a blood sample for NOAC concentration measurement or who decline to give informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of anticoagulant therapy in atrial fibrillation patients, potentially reducing the risk of serious complications.
How similar studies have performed: While the approach of linking NOAC concentration to clinical outcomes is being explored, this specific study may provide novel insights into the management of atrial fibrillation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age more than 20 years. * Under NOAC therapy. Exclusion Criteria: * Failed to provide at least one blood sample for NOAC concentration measurement. * Declined to provide informed consent
Where this trial is running
Taipei, Please Select and 1 other locations
- National Taiwan University Hospital — Taipei, Please Select, Taiwan (Recruiting)
- National Taiwan University Hospital — Taipei, Taiwan (Not_yet_recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.