Examining the link between CT scans, bone density, and hearing loss in otosclerosis patients
Radiological and Audiological Correlation in Otosclerosis: a Prospective Case-Control Study Evaluating Temporal Bone CT, Bone Mineral Density, and Hearing Loss
Hacettepe University · NCT06830187
This study is trying to see if there's a connection between CT scan results, bone density, and hearing loss in adults with otosclerosis compared to those without the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 86 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hacettepe University (other) |
| Locations | 1 site (Ankara) |
| Trial ID | NCT06830187 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the relationship between temporal bone CT findings, bone mineral density (BMD), and hearing loss in adults diagnosed with otosclerosis. Researchers will compare patients with otosclerosis to a control group without the condition to assess correlations between CT density values and hearing loss severity. Participants will undergo BMD assessments, serum vitamin D level measurements, and audiological testing, utilizing existing CT scans from routine evaluations. The study seeks to uncover potential systemic bone metabolism markers associated with otosclerosis.
Who should consider this trial
Good fit: Ideal candidates include adults diagnosed with otosclerosis who have undergone relevant imaging and audiological assessments.
Not a fit: Patients with primary metabolic bone diseases or those on medications affecting bone metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the relationship between bone health and hearing loss in otosclerosis, potentially leading to improved treatment strategies.
How similar studies have performed: While the specific approach of this study is relatively novel, similar studies have explored the relationship between bone density and hearing loss, indicating potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria (Otosclerosis Group): * Adults diagnosed with otosclerosis based on audiological and clinical assessment * Patients with available high-resolution CT scans and audiological data * Individuals who have undergone stapedectomy or stapedotomy surgery * Availability of bone mineral density and serum vitamin D data Inclusion Criteria (Control Group): * Patients without otosclerosis but with temporal CT imaging for other indications * No history of conductive or mixed hearing loss * Availability of BMD and vitamin D data Exclusion Criteria: * History of primary metabolic bone diseases (osteoporosis, Paget's disease) * Use of medications affecting bone metabolism (bisphosphonates, corticosteroids) * History of chronic otitis media or prior ear surgeries * Patients who received head and neck radiotherapy
Where this trial is running
Ankara
- Hacettepe University Hospitals — Ankara, Turkey (Türkiye) (RECRUITING)
Study contacts
- Study coordinator: İbrahim Emir Yeşil, MD
- Email: iemiryesil@gmail.com
- Phone: +905019103056
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Otosclerosis of Middle Ear, Bone Density, Vitamin D Deficiency, Otosclerosis, Temporal Bone CT, Bone Mineral Density, Serum Vitamin D, Audiology