Examining the link between blood microRNAs and Alzheimer's disease risk and severity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between peripheral blood microRNAs and the risk and severity of Alzheimer's Disease (AD). It aims to identify potential biomarkers that could help in understanding the progression of AD and its underlying mechanisms. The study includes both Alzheimer's patients who meet specific diagnostic criteria and healthy volunteers without cognitive impairment. By analyzing blood samples, researchers hope to uncover insights into how microRNAs may influence the disease's development and severity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Alzheimer's disease patients:

* Meet the diagnostic criteria of NINCDS-ADRDA for AD
* Clinical Dementia Scale (CDR) score ≥0.5

Healthy volunteers:

* No complaints or symptoms of cognitive impairment
* MMSE score is higher than the threshold value

Exclusion Criteria:

Alzheimer's disease patients:

* Dementia or cognitive impairment due to other diseases
* Combined with delirium
* A history of drug abuse
* Severe deafness, aphasia and other impact scale score

Healthy volunteers:

* had an organic brain lesion
* Suffering from other major physical diseases: such as severe immune diseases

Where it's running

• Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting

Study contacts

• Principal investigator: Kai Zheng — Tongji Hospital
• Study coordinator: Jiajie Chen
• Email: 1005843466@qq.com
• Phone: 0086-15927561646

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.