Examining the link between a specific oral bacteria and obesity in patients with gum disease
Non-interventional Study Exploring the Relationship Between Porphyromonas Gingivalis and Obesity in Patients With Periodontitis
This study is trying to see if a specific type of bacteria in the mouth is linked to obesity in people with gum disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 311 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Trial ID | NCT05942703 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between Porphyromonas gingivalis, an oral bacterium, and obesity in individuals suffering from periodontitis. It aims to assess the average levels of this bacterium in the saliva of obese patients (BMI ≥ 30) who have periodontitis. Participants will be recruited during routine visits to the periodontology department, where they will provide saliva samples for analysis. The study employs a comparative cross-sectional design, incorporating both retrospective and prospective participant recruitment.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have been diagnosed with periodontitis and are classified as obese.
Not a fit: Patients who have taken antibiotics, prebiotics, or probiotics in the month prior to inclusion, or those with certain health conditions that contraindicate participation, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the role of oral bacteria in obesity, potentially leading to new preventive or therapeutic strategies.
How similar studies have performed: While the relationship between gut microbiota and obesity has been explored, the specific focus on Porphyromonas gingivalis in the context of periodontitis and obesity is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * over 18 years old * having periodontitis * able to receive information on the course of the study and to understand the information form to participate in the study. * having given their non-objection to participate in the study Exclusion Criteria: * Having taken antibiotics, prebiotics or probiotics in the month prior to inclusion * During pregnancy or breastfeeding * With a history of oral surgery in the month prior to inclusion * At risk of infection (existence of one or more known chronic infectious diseases) * Suffering from a general pathology contraindicating the performance of diagnostic procedures such as periodontal probing (patients at high risk of infective endocarditis according to the French National Agency for the Safety of Medicines and Products of Health ANSM)
Where this trial is running
Toulouse
- UHToulouse — Toulouse, France (Recruiting)
Study contacts
- Principal investigator: Sara LAURENCIN, MD — University Hospital, Toulouse
- Study coordinator: Sara LAURENCIN, MD
- Email: laurencin.s@chu-toulouse.fr
- Phone: 0561344473
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.