Examining the impact of tumor thickness and location on lymph nodes in tongue cancer
Assessment of the Effect of Tumor Thickness and Site on Level IV Cervical Lymph Nodes in Squamous Cell Carcinoma of the Tongue and Floor of the Mouth: A Case Series Study
This study is testing how the thickness and location of tongue cancer tumors affect the chances of cancer spreading to nearby lymph nodes in patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 15 Years to 60 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06169605 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between tumor thickness and the involvement of level IV cervical lymph nodes in patients with squamous cell carcinoma of the tongue and floor of the mouth. It aims to determine if specific subsites of the tongue and certain tumor thickness cutoffs correlate with the risk of occult metastases in these lymph nodes. The approach involves the surgical removal of the primary tumor and neck dissection to assess lymph node involvement. The findings could provide valuable insights into treatment strategies for oral cavity cancers.
Who should consider this trial
Good fit: Ideal candidates are patients aged 15 to 60 with squamous cell carcinoma of the tongue or floor of the mouth.
Not a fit: Patients with recurrent squamous cell carcinoma or those who have undergone radiation or chemotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance surgical decision-making and improve patient outcomes by identifying patients at higher risk for lymph node metastasis.
How similar studies have performed: While there is limited data on this specific correlation, similar studies have explored lymph node involvement in head and neck cancers, indicating potential for meaningful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with squamous cell carcinoma of the tongue and floor of the mouth. * Age group: from 15 to 60 years old * No sex predilection Exclusion Criteria: * Patients with recurrent squamous cell carcinoma of the tongue and floor of the mouth. * Irradiated patients or those taking chemotherapy.
Where this trial is running
Cairo
- Faculty of Dentistry, Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Mohamed Shawky, MSc — Cairo University
- Study coordinator: Mohamed Shawky, MSc
- Email: m.shawky1993@gmail.com
- Phone: +201223933897
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.