Examining the impact of different force levels on canine tooth movement in orthodontics
Official title: A Randomized Clinical Trial Comparing the Effect of Force Magnitude on the Rate of Canine Retraction and Gingival Crevicular Fluid Proteome Profile
Run by UConn Health · NCT06668194 · Data updated 2026-11-12
This study tests if using lighter or heavier forces during orthodontic treatment helps move canine teeth more effectively in teenagers aged 11 to 16.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 11 Years to 16 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | UConn Health Academic / other |
| Locations | 1 site (Farmington, Connecticut) |
| Status | Recruiting |
| Started | November 13, 2024 |
| Main results expected | October 1, 2027 |
| Study ends | April 1, 2028 |
| Registry record updated | November 26, 2024 |
| Trial ID | NCT06668194 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adolescents aged 11 to 16 requiring upper first premolar extractions due to tooth crowding.
✕Probably not a fit
Patients with non-extraction treatment plans or those outside the age range of 11 to 16 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how varying force levels during orthodontic canine retraction affect tooth movement and the composition of gingival crevicular fluid. Participants aged 11 to 16 will undergo a split-mouth design where one side receives light force (150g) and the other heavy force (400g) using NiTi coil springs. Data will be collected through dental molds, x-rays, and gingival fluid samples at the start of treatment and during follow-up visits. The goal is to determine if there is a significant difference in canine movement rates between the two force levels.
Why it matters
Potential benefit: If successful, this study could optimize orthodontic treatment protocols, leading to more effective and comfortable tooth movement for patients.
How similar studies have gone: Previous studies have shown varying success with different force levels in orthodontics, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy patient, non-smoker * Age: 11 - 16 years of age, inclusive. * A full complement of dentition (central incisor to 1st molar) in the four quadrants, except second molars * Patients requiring at least upper bilaterally maxillary 1st premolar extraction as a treatment plan (Class I bimaxillary protrusion/ crowding or Class II maxillary dentoalveolar protrusion/ crowding) * At least 5 mm of space left between canine and 2nd premolar to be closed at the time of canine retraction * At least six months after the extraction of first premolars and in a 0.019 x 0.025-inch stainless steel archwire in the maxilla * The ability to read and understand English and to provide informed consent Exclusion Criteria: * Patients under 11 years of age and over the age of 16. * Non-extraction treatment plan * Extraction of maxillary tooth other than first premolars bilaterally. * Evidence of poor oral hygiene * Evidence of previous root resorption * Missing or impacted tooth in any of the quadrant except 3rd molars. * Medical issues that affect tooth movement * Inability to provide oral and written consent to participate. * Patient on medications that may alter bone metabolisms like bisphosphonates, oral contraceptives, or PTH (parathyroid hormone) * Chronic illness or syndromic patients. * Pregnant women, prisoners, and decisional impaired
Where it's running
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Department of Orthodontics
Farmington, Connecticut, United States Recruiting
Study contacts
- Principal investigator: Flavio Uribe, DDS, MDentSc — UConn Health
- Study coordinator: Flavio Uribe, DDS, MDentSc
- Email: furibe@uchc.edu
- Phone: 860-679-2664
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Gingival Phenotype and Dental Crowding in Children
This study looks at how the thickness and other features of gums in kids relate to how their teeth crowd and how the gums might react to moving teeth with braces.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.