Examining the effects of lung collapse on heart pressure after heart transplantation in children
Impact of Atelectasis and Lung Recruitment on RVEDP Measurement in Children Undergoing Cardiac Catheterization for Surveillance Following Orthotropic Heart Transplantation
This study looks at how lung collapse affects heart pressure in children who have had a heart transplant to help improve their care after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Sex | All |
| Sponsor | Baylor College of Medicine Academic / other |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT06140810 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the impact of atelectasis, or lung tissue collapse, on intracardiac pressures in children who have undergone orthotropic heart transplantation. Following the transplant, these patients typically undergo routine cardiac catheterizations under general anesthesia, which can lead to atelectasis. The study aims to determine how this condition affects pressure measurements critical for monitoring potential rejection of the transplanted heart. By understanding this relationship, the study seeks to improve post-transplant care and treatment regimens.
Who should consider this trial
Good fit: Ideal candidates include children who have undergone orthotropic heart transplantation and require routine cardiac catheterization under general anesthesia.
Not a fit: Patients who may not benefit include those with known acute rejection, significant pulmonary issues, or those who have had previous lung surgeries.
Why it matters
Potential benefit: If successful, this study could enhance monitoring techniques and treatment strategies for children post-heart transplantation, potentially improving patient outcomes.
How similar studies have performed: While the specific impact of atelectasis on intracardiac pressures post-heart transplantation is not widely studied, related research on anesthesia effects in pediatric populations suggests potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients having undergone orthotropic heart transplantation * Patients requiring routine heart catheterization for post-transplant surveillance * General anesthesia Exclusion Criteria: * Patient/parental refusal * Patients with suspected or known acute rejection * Known anti-rejection medication non-compliance * Patients within 1 year following heart transplant * Home oxygen requirement * Previous lung surgery (e.g., lobectomy) other than biopsy * Lung transplantation * Known pulmonary fibrosis * Known pulmonary hypertension (\>1/2 systemic) * Sedation without the use of an airway device * Active respiratory infection -Inability to provide recruitment breaths \>25mmHg -Cardiomegaly * Recipient/donor size mismatch
Where this trial is running
Houston, Texas
- Texas Childrens Hospital — Houston, Texas, United States (Recruiting)
Study contacts
- Principal investigator: adam adker, MD — Texas Childrens Hospital
- Study coordinator: Adam Adler, MD
- Email: adam.adler@bcm.edu
- Phone: 8328245800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.