Examining the effects of low-intensity focused ultrasound on brain signals related to pain
Official title: Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals
Run by Virginia Polytechnic Institute and State University · NCT05303415 · Data updated 2026-11-12
This study is testing if a gentle ultrasound treatment can change brain signals related to pain to help people manage their pain better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Virginia Polytechnic Institute and State University Academic / other |
| Locations | 1 site (Roanoke, Virginia) |
| Status | Recruiting |
| Started | May 6, 2022 |
| Main results expected | May 2027 |
| Study ends | December 2027 |
| Registry record updated | June 8, 2026 |
| Trial ID | NCT05303415 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy volunteers who are fluent in English and do not have any contraindications for MRI or CT scans.
✕Probably not a fit
Patients with a history of neurological disorders, active medical conditions affecting the CNS, or those who are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how noninvasive brain stimulation using low-intensity focused ultrasound (LIFU) affects brain activity and signals related to pain. Participants will undergo MRI and CT imaging to assess changes in brain function before and after LIFU treatment. The study includes monitoring of physiological responses such as heart rate and blood pressure, as well as behavioral assessments through questionnaires. The research aims to provide insights that could have clinical implications for managing pain and other related conditions.
Why it matters
Potential benefit: If successful, this study could lead to new noninvasive treatments for pain management.
How similar studies have gone: While the approach of using low-intensity focused ultrasound is relatively novel, similar studies in neuromodulation have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy volunteers, all ethnicities, who understand and speak English. Exclusion Criteria: Claustrophobia (scanning environment may be uncomfortable). Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. Contraindications to CT: pregnancy Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's) History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor) History of head injury resulting in loss of consciousness for \>10 minutes. History of alcohol or drug dependence (through self-report).
Where it's running
-
Fralin Biomedical Research Institute
Roanoke, Virginia, United States Recruiting
Study contacts
- Study coordinator: Jessica W Florig, MPH
- Email: legonlab@vtc.vt.edu
- Phone: 540-526-2261
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.