Examining the effects of anesthesia on brain development in children with congenital scoliosis
Long-term Effect of General Anesthesia Before School Age on Neurodevelopment in Children With Congenital Scoliosis
This study looks at how being put under general anesthesia during scoliosis surgery might affect the thinking and behavior of children aged 6 to 16 with congenital scoliosis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 6 Years to 16 Years |
| Sex | All |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06315933 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the potential long-term neurocognitive effects of general anesthesia exposure in children diagnosed with congenital scoliosis. It aims to assess whether single or multiple long-duration anesthesia exposures during posterior scoliosis correction surgery impact cognitive function and behavior. The study will involve children aged 6 to 16 years, evaluating their neurodevelopmental outcomes post-anesthesia. The findings could provide critical insights into the safety of anesthesia in this vulnerable population.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 6 to 16 years who have been diagnosed with congenital scoliosis.
Not a fit: Patients with cognitive impairments, mental disorders, or other neurological conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help determine safe anesthesia practices for children with congenital scoliosis, potentially improving their long-term cognitive outcomes.
How similar studies have performed: While some studies have suggested that short-term anesthesia exposure does not affect long-term neurodevelopment, this specific investigation into congenital scoliosis is novel and has not been extensively researched.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with congenital scoliosis * 6-16 years old at the time of assessment Exclusion Criteria: * Cognitive impairment caused by congenital, traumatic or other reasons; * Existence of mental or psychological disorders; * There are factors that may affect neurological development, including any known central nervous system disease, neurological injury, or history of neonatal asphyxia; * Unable to cooperate with cognitive function tests; * The child is unable to communicate in Chinese.
Where this trial is running
Beijing, Beijing Municipality
- Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Lulu Ma, Dr. — Peking Union Medical College Hospital
- Study coordinator: Lulu Ma, Dr.
- Email: malulu@pumch.cn
- Phone: 0086-10-13811049619
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.