Examining the airway epithelium in children with post-infectious bronchiolitis obliterans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the morphological and functional characteristics of the respiratory epithelium in children aged 1 month to 6 years who have been hospitalized with adenovirus or rhinovirus infections. The research aims to identify differences in the nasal epithelium of children who progress to post-infectious bronchiolitis obliterans (PIBO) compared to those who do not. By analyzing the airway epithelium, the study seeks to enhance understanding of the pathophysiology associated with PIBO, which is often diagnosed late and lacks established treatment protocols. The study is conducted at a single center, the Timone Enfant University Hospital in Marseille, France.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Children from 1 month to 6 years hospitalized at the Timone Enfant University Hospital
2. Diagnosis of an adenovirus or rhinovirus respiratory infection confirmed on a nasal swab, made upon arrival as part of the child's initial care
3. Consent form read, understood, approved and signed by parents before any study procedure
4. Affiliation to a social security scheme or beneficiary of such a scheme

The inclusion criteria for children who were not hospitalized when diagnosed with an adenovirus and rhinovirus respiratory infection at the Timone Enfant University Hospital are:

1. Children from 1 month to 6 years old transferred to the Timone Enfant University Hospital
2. Show the following signs:

   has. Clinical: clinical signs persist 6 weeks after a viral infection: tachypnea, wheezing and/or persistent hypoxemia b. Scan: mosaic appearance +/- bronchiectasis, atelectasis vs. +/- EFR if performed: obstructive ventilatory disorder not or only slightly reversible after bronchodilators
3. Consent form read, understood, approved and signed by parents before any study procedure
4. Affiliation to a social security scheme or beneficiary of such a scheme

Exclusion Criteria:

1. Refusal of participation in the study by the family will be a reason for non-inclusion, as well as in the absence of parental authority.
2. The existence of an underlying chronic pulmonary pathology (e.g. cystic fibrosis, ciliary dyskinesia).
3. A coagulation pathology.

Where it's running

• Aphm
  Marseille, France Recruiting

Study contacts

• Principal investigator: Julie MAZENQ, PhD — APHP Marseille
• Study coordinator: Julie MAZENQ, PhD
• Email: julie.mazenq@ap-hm.fr
• Phone: 0491386808

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using belumosudil to prevent or treat bronchiolitis obliterans in stem cell transplant patients

  This study is testing if a new medication called belumosudil can help prevent or treat bronchiolitis obliterans in patients who have recently had a stem cell transplant.

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• Investigating abnormal cells in patients with bronchiolitis obliterans syndrome

  This study is testing whether looking at certain abnormal cells in the blood and lungs of patients with bronchiolitis obliterans syndrome after a transplant can help doctors find this condition earlier.

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• Long-term observation of lung injury in children after stem cell transplants

  This study looks at children who have had stem cell transplants to see how often they develop lung problems and how these issues affect their health over time.

  Recruiting at 9 sites Children's Hospital Medical Center, Cincinnati · San Francisco, California and 8 other locations · NCT04098445

• Inhaled LAM-001 for lung transplant patients with bronchiolitis obliterans syndrome

  This study is testing if an inhaled medication called LAM-001 can help lung transplant patients with bronchiolitis obliterans syndrome feel better and improve their lung function.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT06018766

• Biomarkers for Response to ECP in Lung Transplant Patients with CLAD

  This study tests early biomarkers from blood and MRI to see if extracorporeal photopheresis helps lung transplant patients with chronic lung allograft dysfunction.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT07434869

• Airway basal stem cell treatment for children with bronchiolitis obliterans

  This trial will try airway basal stem cell treatment to see if it is safe and helps children (28 days to 18 years) with bronchiolitis obliterans who have severe lung function loss or need ongoing oxygen or ventilator support.

  Recruiting Early Phase 1 Regend Therapeutics · Shanghai · NCT07239895

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.