Examining sleep issues in long-term childhood cancer survivors
Characterizing Sleep Among Long-term Survivors of Childhood Cancer
This study is trying to find out how common sleep problems are among long-term survivors of childhood cancer, like leukemia and brain tumors, by having them complete surveys and sleep tests.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Memphis, Tennessee) |
| Trial ID | NCT05480904 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on long-term survivors of childhood cancer who were treated at St. Jude Children's Research Hospital. It aims to estimate the prevalence of sleep disorders among survivors of acute lymphoblastic leukemia (ALL), central nervous system (CNS) tumors, and non-CNS solid tumors. Participants will undergo remote polysomnography and complete surveys to assess their sleep patterns and disorders. The study will enroll approximately 120 participants, with 40 from each diagnostic group, and will include both on-campus and remote activities.
Who should consider this trial
Good fit: Ideal candidates are individuals over 18 years old who were diagnosed with ALL, CNS tumors, or non-CNS solid tumors and are at least 5 years post-diagnosis.
Not a fit: Patients currently receiving treatment for sleep disorders or with certain exclusions, such as those with craniopharyngioma or Hodgkin Lymphoma, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of sleep disorders in childhood cancer survivors.
How similar studies have performed: While this study explores a specific population, similar studies have shown that sleep disorders are prevalent among cancer survivors, indicating potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant in SJLIFE and \> 5 years from diagnosis. * \>18 years of age at time of enrollment. * Diagnosed with ALL (treated with CRT or chemotherapy only) or CNS tumors (posterior fossa tumors or supratentorial tumors) or non-CNS solid tumors (with abdominal or chest radiation or bilateral retinoblastoma survivors). * Participant was less than 21 years of age at time of diagnosis. * Speaks and understands English (polysomnography device speaks to patients only in English). * Remote participant must have Wi-Fi access Exclusion Criteria: * Estimated intelligence score \<80. * Currently prescribed an intervention for a sleep disorder. * Survivor of craniopharyngioma. * Survivor of Hodgkin Lymphoma. * Relapsed or treated with hematopoietic stem cell therapy. * Brain injury unrelated to cancer diagnosis or therapy. * Pulmonary injury unrelated to cancer diagnosis or therapy.
Where this trial is running
Memphis, Tennessee
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Kevin Krull, PhD — St. Jude Children's Research Hospital
- Study coordinator: Kevin Krull, PhD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.