Examining sex differences in coronary microvascular dysfunction in patients with non-obstructive coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the differences in coronary microvascular dysfunction between sexes in patients who experience chest pain but have no significant coronary artery stenosis. Patients will undergo adenosine stress echocardiography to assess coronary microvascular function by measuring coronary blood flow velocities at specified intervals after adenosine infusion. The study focuses on understanding how these differences may impact the management and treatment of microvascular angina.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Typical/atypical chest pain or ischemic symptoms including dyspnea
* No significant coronary artery stenosis (\<50% stenosis) in coronary angiography or computed tomography

Exclusion Criteria:

* ≥ Moderate valvular heart disease
* Congenital heart disease
* Chronic renal failure (estimated glomerular filtration rate \<30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
* Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
* Receiving anticancer drugs
* Vasculitis associated with autoimmune diseases
* Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients

Where it's running

• Korea University Anam Hospital
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Seong-Mi Park, PhD — Korea University Anam Hospital
• Study coordinator: So Ree Kim, PhD
• Email: soree8826kim@gmail.com
• Phone: 82-10-9453-4810

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.