Examining sex differences in coronary microvascular dysfunction in patients with non-obstructive coronary artery disease
Sex Difference of Coronary Microvascular Dysfunction Evaluated by Coronary Flow Reserve in Patients With Non-obstructive Coronary Artery Disease
This study is trying to see if men and women with chest pain but no major blockages in their heart arteries have different issues with small blood vessels in the heart.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Korea University Anam Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT06076551 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the differences in coronary microvascular dysfunction between sexes in patients who experience chest pain but have no significant coronary artery stenosis. Patients will undergo adenosine stress echocardiography to assess coronary microvascular function by measuring coronary blood flow velocities at specified intervals after adenosine infusion. The study focuses on understanding how these differences may impact the management and treatment of microvascular angina.
Who should consider this trial
Good fit: Ideal candidates include individuals experiencing typical or atypical chest pain with no significant coronary artery stenosis.
Not a fit: Patients with moderate valvular heart disease, congenital heart disease, or those with chronic renal failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and treatment strategies for patients suffering from microvascular angina, particularly by considering sex-specific differences.
How similar studies have performed: While there is ongoing research in coronary microvascular dysfunction, this specific focus on sex differences in patients with non-obstructive coronary artery disease is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Typical/atypical chest pain or ischemic symptoms including dyspnea * No significant coronary artery stenosis (\<50% stenosis) in coronary angiography or computed tomography Exclusion Criteria: * ≥ Moderate valvular heart disease * Congenital heart disease * Chronic renal failure (estimated glomerular filtration rate \<30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis * Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension * Receiving anticancer drugs * Vasculitis associated with autoimmune diseases * Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients
Where this trial is running
Seoul
- Korea University Anam Hospital — Seoul, South Korea (Recruiting)
Study contacts
- Principal investigator: Seong-Mi Park, PhD — Korea University Anam Hospital
- Study coordinator: So Ree Kim, PhD
- Email: soree8826kim@gmail.com
- Phone: 82-10-9453-4810
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.