Examining retinal blood vessels to understand systemic diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between retinal microvascularization and systemic vascular damage. It aims to identify predictive indicators of chronic inflammatory diseases by analyzing the health of small blood vessels in the retina using non-invasive imaging techniques. Patients with systemic vascular conditions and healthy controls will be monitored over time to assess the progression of these diseases. The study utilizes retinal imaging and biological check-ups to gather data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For the \"patients with systemic vascular disease\" group

* Patients who have given oral, free and informed consent
* Patients with either :

  * systemic vascular pathology
  * high cardiovascular risk
  * inflammatory vascular pathology
  * preeclampsia during pregnancy

The study will also be offered to patients who have already had an OCT-A examination as part of their routine care, in order to follow them over time.

For the \"healthy control\" group

* Patients who have given free, oral and informed consent
* Patients with no prior systemic or vascular inflammatory pathology, and no high cardiovascular risk
* Non-diabetic patients
* Pregnant patients with risk-free pregnancies recruited from the gynecology department of CHU Dijon Bourgogne OR
* Adult patients without maculopathy recruited from the Ophthalmology Department of CHU Dijon Bourgogne

Exclusion Criteria:

* For the \"patients with systemic vascular disease\" group
* Ophthalmological history in both eyes (vascular and degenerative macular pathologies)
* Protected patient :

  * Minor patient
  * Patient under legal protection (guardianship, curatorship, court order)
  * Patient unable to give consent Person not affiliated to a social security scheme
  * Breast-feeding women
* Person with a contraindication to Tropicamide
* OCT-A signal strength \< 7

For the \"healthy control\" group

* Any pathology studied in the case group
* Ophthalmological history in both eyes (vascular and degenerative macular pathologies)
* Type 1 or type 2 diabetes
* Person with a contraindication to Tropicamide
* Protected person :

  * Minor
  * Person under legal protection (guardianship, curatorship, court order)
  * Person unable to give consent
  * Person not affiliated to a social security scheme
  * Breast-feeding women
* OCT-A signal strength \< 7

Where it's running

• Chu Dijon Bourogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: Louis ARNOULD
• Email: Louis.arnould@chu-dijon.fr
• Phone: 0380293453

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.