Examining Natural Killer Cells in Severe Asthma Patients
Official title: Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects: Identification of Biomarkers, Response During Virus-induced Exacerbations, and Interaction With Bronchial Epithelial Cells
Run by Institut National de la Santé Et de la Recherche Médicale, France · NCT06015256 · Data updated 2026-11-12
This study is testing how natural killer cells in the immune system affect people with severe asthma, especially during asthma attacks caused by viruses, by comparing them to healthy individuals.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 448 (estimated) |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Locations | 1 site (Marseille) |
| Status | Recruiting |
| Started | September 7, 2023 |
| Main results expected | September 2028 |
| Study ends | September 2030 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT06015256 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 with a confirmed diagnosis of severe asthma, either controlled or uncontrolled.
✕Probably not a fit
Patients with mild asthma or those not meeting the inclusion criteria, such as minors or individuals under legal protection, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the role of natural killer (NK) cells in patients with severe asthma compared to healthy control subjects. It aims to understand how these immune cells contribute to asthma exacerbations, particularly those triggered by viral infections. Participants will provide blood samples for analysis, allowing researchers to characterize NK cell activity and function in the context of severe asthma. The study focuses on patients diagnosed with severe asthma, both controlled and uncontrolled, as well as healthy volunteers.
Why it matters
Potential benefit: If successful, this research could lead to new insights into asthma management and potential therapeutic targets for patients with severe asthma.
How similar studies have gone: While the role of NK cells in asthma is not well-established, similar studies investigating immune responses in asthma have shown promising results, suggesting potential for novel insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Cases asthma controlled, uncontrolled excluding exacerbation, uncontrolled asthma exacerbation, and healthy volunteers: * Consent form read, understood, approved and signed before any study procedure * Membership of a social security scheme or beneficiary of such a scheme * Patient aged over 18 Cases asthma controlled, uncontrolled excluding exacerbation, uncontrolled exacerbation: \- Diagnosis of severe asthma confirmed by a respirologist at an expert centre Case asthma controlled: \- Asthma control confirmed by a lung specialist from an expert centre Case uncontrolled asthma excluding exacerbation: \- Uncontrolled asthma confirmed by a lung specialist from an expert centre Case uncontrolled asthma with exacerbation: \- Current exacerbation Exclusion Criteria: Cases asthma controlled, uncontrolled excluding exacerbation, uncontrolled asthma exacerbation, and healthy volunteers: * Person subject to a legal protection measure * Vulnerable population: minors, persons under guardianship or trusteeship or persons deprived of their rights to liberty by court order. * women with a known pregnancy * Inability or refusal to comply with research requirements * Active or weaned smoker \> 15 PA * Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or opioids in the 10 days prior to inclusion Case patient with asthma: \- Coexistence of a chronic inflammatory disease other than asthma Case healthy volunteers: \- Coexistence of an inflammatory pathology Exclusion criteria: Cases asthma: Pregnancy during follow-up Cases healthy volunteers: Total IgE level greater than 100 kU/L (measured on the study sample)
Where it's running
-
Hôpital NORD - AP-HM, Clinique des bronches, de l'allergie et du sommeil
Marseille, France Recruiting
Study contacts
- Study coordinator: Pascal Chanez, PU-PH
- Email: pascal.chanez@univ-amu.fr
- Phone: +334.91.96.58.64
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Rademikibart IV for Acute Asthma and COPD Exacerbation
This study tests a one-time IV dose of rademikibart to help people with acute asthma or COPD flare-ups who need urgent care.
-
Explainable AI helps families manage obesity in kids and young adults with diabetes or asthma
This study tests a family-centered digital program to help adolescents and young adults with overweight or obesity, including those with Type 1 diabetes or asthma, see if the program improves wellbeing and healthy habits over 3 months.
-
Post-Exacerbation Asthma Telecare
This trial tests whether a structured remote pulmonology follow-up after an asthma flare‑up can reduce repeat exacerbations compared with usual care.
-
Short-term air pollution and exercise effects on children's lungs
This project will test if outdoor exercise on higher-pollution days affects primary-school children's lungs more than resting outdoors.
-
ASMact: Managing bronchial asthma attacks in children
This study tries a GINA 2025-based staff education and care-standardization approach to see if emergency treatment for children aged 6–17 with acute asthma attacks improves outcomes.
-
45th Multicenter Airway Collaboration on ED initiation of Airsupra
This trial tests whether giving Airsupra in the emergency department reduces asthma recurrence over three months for adults sent home on a short course of steroids.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.