Examining MRI changes in spinal cord disorders
MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders
University of Zurich · NCT02170155
This study looks at how changes in the spinal cord and fluid around it can help us understand spinal cord disorders better and improve early diagnosis and treatment for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 350 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Zurich (other) |
| Locations | 1 site (Zurich, Canton of Zurich) |
| Trial ID | NCT02170155 on ClinicalTrials.gov |
What this trial studies
This observational study aims to understand the onset and progression of spinal cord disorders by analyzing structural and dynamic changes in the spinal cord and cerebrospinal fluid (CSF) using MRI. It will explore the relationships between MRI parameters, clinical disability, and electrophysiology. Additionally, in some patients undergoing decompressive surgery, CSF pressure will be measured perioperatively to investigate correlations between functional limitations, structural changes, and spinal pressure. The goal is to facilitate early diagnosis and therapy to prevent disability progression.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-80 with cervical spinal injuries.
Not a fit: Patients with other neurological or psychiatric disorders, seizures, MRI incompatibility, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early diagnosis and treatment strategies for spinal cord disorders.
How similar studies have performed: While similar studies have explored MRI changes in spinal cord disorders, this specific approach focusing on CSF flow and pressure in relation to structural changes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cervical injury * Informed consent * Age 18-80 * CSM Exclusion Criteria: * No other neurologic disorder and psychiatric disorder * Seizure * MRI incompatibility * Pregnancy
Where this trial is running
Zurich, Canton of Zurich
- University of Zurich, Balgrist University Hospital — Zurich, Canton of Zurich, Switzerland (RECRUITING)
Study contacts
- Study coordinator: Patrick Freund, PhD
- Email: patrick.freund@balgrist.ch
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Spinal Injury