Examining lymphocyte changes in critically ill patients
Evolution of the Lymphocyte Phenotype in Patients with Infection in Intensive Care Unit
This study is trying to see how changes in certain immune cells affect critically ill patients in the ICU to help improve their treatment and recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Brest Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Brest) |
| Trial ID | NCT06415474 on ClinicalTrials.gov |
What this trial studies
This study investigates the evolution of lymphocyte phenotypes in patients admitted to the intensive care unit with conditions such as severe polytrauma, neurological injuries, or infections. By monitoring these patients over time, the study aims to understand the phenomenon of immunoparalysis, which can lead to prolonged infections. The primary intervention involves a lymphocyte phenotyping procedure to assess immune responses in these critically ill patients. The findings could provide insights into improving patient management and outcomes in intensive care settings.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and over who are undergoing postoperative monitoring after esophagectomy or have severe infections or neurological injuries requiring prolonged intubation.
Not a fit: Patients with hereditary immune deficiencies, malignant hemopathies, or those on immunosuppressive treatments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of immune responses in critically ill patients, potentially leading to better management of infections.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have explored lymphocyte phenotyping in critically ill patients, indicating potential for valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Postoperative esophagectomy surveillance within the last 24 hours. * Patients with intra-abdominal infection * Neurological patients with intubation planned for more than 24 hours (subarachnoid hemorrhage with coma, severe head trauma, ischemic or hemorrhagic stroke with coma). * Polytrauma with intubation planned for more than 24 hours * Patient aged 18 and over * Patient with social security coverage Non-inclusion criteria : * Hereditary immune deficiency HIV-AIDS * Malignant hemopathies * Immunosuppressive treatment other than corticosteroid therapy or chemotherapy * Patient under legal protection * Pregnant or breast-feeding women
Where this trial is running
Brest
- CHU de Brest — Brest, France (Recruiting)
Study contacts
- Study coordinator: Etienne BOTQUELEN, MD
- Email: etienne.botquelen@chu-brest.fr
- Phone: 02 98 34 72 88
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.