Examining lymphatic function during mechanical ventilation
Effect of Mechanical Ventilation on Peripheral Lymphatic Function - do Elevated Intrathoracic Pressure Impact Lymphatic Flow?
This study is testing how changes in pressure during mechanical ventilation affect the lymphatic system in patients having surgery for jaw problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | Rigshospitalet, Denmark Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT05770752 on ClinicalTrials.gov |
What this trial studies
This study investigates how changes in intrathoracic pressure affect lymphatic function in patients undergoing surgery for jaw malformations who are mechanically ventilated. The research will utilize Near-Infrared Fluorescence Imaging to assess the lymphatic vessels in the lower limbs. Participants will be evaluated on two occasions: once to establish baseline lymphatic function and again during surgery under a specific ventilation protocol with altered pressure settings.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old undergoing surgery for jaw malformations and who are cardiopulmonary healthy.
Not a fit: Patients with a history of cardiac, pulmonary, or lymphatic diseases, as well as those with peripheral edema or chronic infectious diseases, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve understanding of lymphatic function during mechanical ventilation, potentially leading to better management of patients requiring such interventions.
How similar studies have performed: While the specific approach of examining lymphatic function during mechanical ventilation is novel, related studies on lymphatic function have shown varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing surgery for jaw malformations * Age \> 18 years * Informed consent * Cardiopulmonary healthy Exclusion Criteria: * History of Cardiac disease * History of pulmonary disease * History of lymphatic disease * Peripheral edema * Chronic infectious disease * Age \> 30 years * BMI \> 30
Where this trial is running
Copenhagen
- Copenhagen University Hospital — Copenhagen, Denmark (Recruiting)
Study contacts
- Principal investigator: Lene Thorup, MD — Copenhagen University Hospital at Herlev
- Study coordinator: Lene Thorup, MD
- Email: lene.thorup.01@regionh.dk
- Phone: +4535457845
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.