Examining knee alignment in osteoarthritis and healthy individuals
Distribution of Coronal Plane Alignment of the Knee Classification in Chinese Osteoarthritic as Well as Healthy Population
This study looks at how knee alignment differs between people with osteoarthritis and healthy individuals to see how it affects surgery results.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 353 (estimated) |
| Sex | All |
| Sponsor | The First Hospital of Jilin University Academic / other |
| Locations | 1 site (Changchun) |
| Trial ID | NCT06158425 on ClinicalTrials.gov |
What this trial studies
This observational study analyzes the coronal plane alignment of the knee in patients with osteoarthritis (OA) and healthy individuals using long-leg radiographs. A total of 246 OA patients and 107 healthy participants were retrospectively examined to compare the CPAK distribution and clinical outcomes of different alignment techniques during total knee arthroplasty. The study employs various machine learning algorithms to classify the constitutional phenotype of arthritic knees. The aim is to enhance understanding of knee alignment and its implications for surgical outcomes.
Who should consider this trial
Good fit: Ideal candidates include individuals with knee osteoarthritis who are scheduled for total knee arthroplasty.
Not a fit: Patients with prior hip arthroplasty or significant bony deficiencies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve surgical techniques and outcomes for patients undergoing knee arthroplasty.
How similar studies have performed: While similar studies have explored knee alignment, this specific approach using machine learning for classification is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - OA group: Data for consecutive OA patients with knee pain who underwent primary TKA by one senior surgeon between August 2021 and July 2023 at a single institution were analyzed retrospectively. Healthy group: Data for consecutive visitors at outpatient clinic who underwent long-leg radiographs but without any sign of cartilage degeneration or medical history of low extremity between January 2023 and July 2023 at the same institution were analyzed retrospectively. Exclusion Criteria: - OA group: prior total hip arthroplasty; obvious bony deficiency of the femur or tibia, simultaneous flexion of the knee and rotation of the leg on radiographs Healthy group: extra-articular deformity of the femur or tibia; simultaneous flexion of the knee and rotation of the leg on radiographs; poor quality image
Where this trial is running
Changchun
- The First Hospital of Jilin University — Changchun, China (Recruiting)
Study contacts
- Study coordinator: Xin Qi, Dr.
- Email: dr.qixin@jlu.edu.cn
- Phone: +8615843073202
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.