Examining kidney blood flow response to exercise in African American adults
Neurovascular Control of Renal Blood Flow During Exercise in African American Adults
This study is testing how exercise affects blood flow to the kidneys in healthy African American adults to see if it helps explain their higher risk for heart and kidney diseases.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | University of Massachusetts, Boston Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT03981640 on ClinicalTrials.gov |
What this trial studies
This study investigates how exercise affects kidney blood flow in healthy African American adults, who are at a higher risk for cardiovascular and renal diseases. It focuses on the sympathetic nervous system's response during physical exertion, cold stress, and mental stress. By understanding the renal vasoconstrictor response to these stressors, researchers aim to identify potential contributors to the increased incidence of cardiovascular and renal disease in this population. The study includes recreationally active participants who self-identify as African American or White and excludes those with certain health conditions.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy, recreationally active African American adults who are fluent in English.
Not a fit: Patients with existing cardiovascular or renal diseases, hypertension, diabetes, obesity, or those who smoke may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and prevention strategies for cardiovascular and renal diseases in African American adults.
How similar studies have performed: While there is limited research on this specific population, studies have shown that understanding sympathetic nervous system responses can provide insights into cardiovascular risks, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Self-report as either African American or White racial identity * Born in United States * Both biological parents identify as same racial identity as participant * Recreationally active (participating in physical activity for at least 20 minutes per day, at least three times per week, but not training for competitive events) * Fluent in English Exclusion Criteria: * Hispanic or Latino * Females who are pregnant or lactating * Cardiovascular or renal disease * Hypertension (blood pressure of more than or equal to 130/80 mmHg) * Diabetes * Obesity (body mass index of more than or equal to 30 kg/m2) * Smoker/Tobacco user * Acute medical conditions * Taking prescribed cardiovascular, antihypertensive, or renal medications
Where this trial is running
Boston, Massachusetts
- University of Massachusetts Boston — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Rachel C Drew, PhD — University of Massachusetts, Boston
- Study coordinator: Rachel C Drew, PhD
- Email: rachel.drew@umb.edu
- Phone: 617-287-4061
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.