Examining Intestinal Blood Flow in Critically Ill Patients

Correlation Between Intestinal Blood Flow and Intestinal Dysfunction in Critically Ill Patients

This study looks at how blood flow to the intestines affects gut health in critically ill patients, especially those with sepsis, using special ultrasound techniques.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Peking Union Medical College Hospital (Academic / other)
• Locations: 1 site (Beijing, Beijing)
• Trial ID: NCT06049979 on ClinicalTrials.gov

What this trial studies

This observational study investigates the relationship between intestinal blood flow and gastrointestinal dysfunction in critically ill patients, particularly those with sepsis. Utilizing Doppler ultrasound techniques, the study measures various blood flow parameters in the superior mesenteric artery to assess intestinal perfusion. The research aims to provide a more accurate understanding of gastrointestinal function by directly monitoring blood flow rather than relying solely on indirect indicators. The study is conducted by experienced ICU physicians at Peking Union Medical College Hospital.

Who should consider this trial

Good fit: Ideal candidates for this study are critically ill patients aged 18 to 80 with sepsis who are expected to stay in the ICU for more than three days.

Not a fit: Patients with coronary heart disease, severe mesenteric artery stenosis, or those who have undergone recent abdominal surgeries may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved management of gastrointestinal dysfunction in critically ill patients, potentially enhancing patient outcomes.

How similar studies have performed: While there has been significant interest in gastrointestinal perfusion monitoring, this specific approach using Doppler ultrasound for direct measurement in critically ill patients is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Patients with sepsis with an expected ICU stay of more than 3 days.
2. ≥18 years of age and \<80 years of age.

Exclusion Criteria:

1. Coronary heart disease, severe mesenteric or abdominal artery stenosis;
2. Fixed body (such as recent spinal surgery or intracranial hypertension);
3. Patients with contraindications for IAP measurement (such as patients who have recently undergone bladder surgery, been injured, or become pregnant;
4. Having undergone abdominal surgery or chest lowering involving the intestines patients undergoing aortic surgery;
5. Poor quality of abdominal ultrasound images;
6. Hydrothorax or ascites.

Where this trial is running

Beijing, Beijing

• Department of Critical Care Medicine of pekin union medical college hospital — Beijing, Beijing, China (Recruiting)

Study contacts

• Study coordinator: Yuankai Zhou, MD

Conditions Critically Ill Patients; Intestinal Blood Flow; Acute gastrointestinal injury