Examining inflammation and biomarkers in organ transplant patients
Official title: Biomarkers and Inflammation in Solid Organ Transplantation: Relationship With Short- and Long-Term Outcomes
Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06774339 · Data updated 2026-11-12
This study looks at inflammation and certain biological markers in organ transplant patients to see if it can help identify those at higher risk for complications and improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 3 sites (Bologna and 2 other locations) |
| Status | Recruiting |
| Started | October 10, 2024 |
| Main results expected | December 2031 |
| Study ends | December 2031 |
| Registry record updated | January 14, 2025 |
| Trial ID | NCT06774339 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients aged 18 and older who have received a solid organ transplant.
✕Probably not a fit
Patients who have not undergone any solid organ transplantation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on adult patients who have undergone solid organ transplantation, including heart, liver, lung, and kidney transplants. It aims to measure various biological markers related to inflammation and cellular aging to identify patients at higher risk for transplant failure and other complications. The study will collect data on cytokines, inflammatory microRNAs, circulating free DNA, and epigenetic markers to help personalize immunosuppressive treatments and improve patient outcomes. The research is being conducted at the IRCCS Azienda Ospedaliero-Universitaria di Bologna.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective immunosuppressive therapies for transplant patients, potentially improving their long-term outcomes.
How similar studies have gone: While the approach of using biomarkers in transplantation is being explored, this specific study's focus on cellular senescence and personalized treatment is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥ 18 years old at the time of enrollment) who have undergone at least one of the following: Liver transplant, Kidney transplant, Heart transplant, Lung transplant during the study period. * Informed consent acquisition. Exclusion Criteria: * none
Where it's running
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IRCCS - Azienda ospedaliero-universitaria di Bologna
Bologna, Italy Recruiting -
IRCCS - Azienda ospedaliero-universitaria di Bologna
Bologna, Italy Recruiting -
IRCCS - Azienda ospedaliero-universitaria di Bologna
Bologna, Italy Recruiting
Study contacts
- Principal investigator: Marco G Masetti, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Marco Masetti, MD
- Email: scompenso.trapiantocuore@aosp.bo.it
- Phone: 0512143725
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This study is testing if measuring certain proteins in blood and saliva can help doctors understand how well transplant medications are working for people who have received solid organ or bone marrow transplants.
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This tests donor-derived virus-specific T cells to treat CMV or adenovirus reactivation in people who have had a solid organ or stem-cell transplant.
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Education and a smartphone app to help organ transplant patients manage life, meds, and symptoms
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.