Examining inflammation and biomarkers in organ transplant patients
Biomarkers and Inflammation in Solid Organ Transplantation: Relationship With Short- and Long-Term Outcomes
IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06774339
This study looks at inflammation and certain biological markers in organ transplant patients to see if it can help identify those at higher risk for complications and improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna (other) |
| Locations | 3 sites (Bologna and 2 other locations) |
| Trial ID | NCT06774339 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on adult patients who have undergone solid organ transplantation, including heart, liver, lung, and kidney transplants. It aims to measure various biological markers related to inflammation and cellular aging to identify patients at higher risk for transplant failure and other complications. The study will collect data on cytokines, inflammatory microRNAs, circulating free DNA, and epigenetic markers to help personalize immunosuppressive treatments and improve patient outcomes. The research is being conducted at the IRCCS Azienda Ospedaliero-Universitaria di Bologna.
Who should consider this trial
Good fit: Ideal candidates are adult patients aged 18 and older who have received a solid organ transplant.
Not a fit: Patients who have not undergone any solid organ transplantation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective immunosuppressive therapies for transplant patients, potentially improving their long-term outcomes.
How similar studies have performed: While the approach of using biomarkers in transplantation is being explored, this specific study's focus on cellular senescence and personalized treatment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥ 18 years old at the time of enrollment) who have undergone at least one of the following: Liver transplant, Kidney transplant, Heart transplant, Lung transplant during the study period. * Informed consent acquisition. Exclusion Criteria: * none
Where this trial is running
Bologna and 2 other locations
- IRCCS - Azienda ospedaliero-universitaria di Bologna — Bologna, Italy (RECRUITING)
- IRCCS - Azienda ospedaliero-universitaria di Bologna — Bologna, Italy (RECRUITING)
- IRCCS - Azienda ospedaliero-universitaria di Bologna — Bologna, Italy (RECRUITING)
Study contacts
- Principal investigator: Marco G Masetti, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Marco Masetti, MD
- Email: scompenso.trapiantocuore@aosp.bo.it
- Phone: 0512143725
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Solid Organ Transplantation