Clinical trial Recruiting at 3 sites Observational Ages 18 and up

Examining inflammation and biomarkers in organ transplant patients

Official title: Biomarkers and Inflammation in Solid Organ Transplantation: Relationship With Short- and Long-Term Outcomes

Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06774339 · Data updated 2026-11-12

This study looks at inflammation and certain biological markers in organ transplant patients to see if it can help identify those at higher risk for complications and improve their treatment.

More Solid Organ Transplantation trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment250 (estimated)
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna
Academic / other
Locations3 sites (Bologna and 2 other locations)
StatusRecruiting
StartedOctober 10, 2024
Main results expectedDecember 2031
Study endsDecember 2031
Registry record updatedJanuary 14, 2025
Trial IDNCT06774339 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adult patients aged 18 and older who have received a solid organ transplant.

Probably not a fit

Patients who have not undergone any solid organ transplantation will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on adult patients who have undergone solid organ transplantation, including heart, liver, lung, and kidney transplants. It aims to measure various biological markers related to inflammation and cellular aging to identify patients at higher risk for transplant failure and other complications. The study will collect data on cytokines, inflammatory microRNAs, circulating free DNA, and epigenetic markers to help personalize immunosuppressive treatments and improve patient outcomes. The research is being conducted at the IRCCS Azienda Ospedaliero-Universitaria di Bologna.

Why it matters

Potential benefit: If successful, this study could lead to more personalized and effective immunosuppressive therapies for transplant patients, potentially improving their long-term outcomes.

How similar studies have gone: While the approach of using biomarkers in transplantation is being explored, this specific study's focus on cellular senescence and personalized treatment is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients (≥ 18 years old at the time of enrollment) who have undergone at least one of the following: Liver transplant, Kidney transplant, Heart transplant, Lung transplant during the study period.
* Informed consent acquisition.

Exclusion Criteria:

* none

Where it's running

  • IRCCS - Azienda ospedaliero-universitaria di Bologna
    Bologna, Italy
    Recruiting
  • IRCCS - Azienda ospedaliero-universitaria di Bologna
    Bologna, Italy
    Recruiting
  • IRCCS - Azienda ospedaliero-universitaria di Bologna
    Bologna, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.