Examining immunity markers in ICU patients with ventilator-associated pneumonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between the recurrence of ventilator-associated pneumonia (VAP) and postaggressive immunoparalysis in patients admitted to the Intensive Care Unit (ICU). It will monitor HLA-DR levels in blood samples taken from participants at the time of inclusion and weekly thereafter. The study seeks to evaluate associations between immunoplegia, severity of initial shock, viral reactivation, and VAP occurrence, with the goal of improving antibiotic therapy and patient outcomes. By identifying patients at risk for infections, the study may inform future immunomodulatory therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient over 18 years old
* Patient admitted in the Intensive Care Unit of the CHIAP
* Patient under mechanical ventilation
* Patient with infectious pneumonia
* Informed Consent Form (ICF) obtained from the patient or emergency ICF obtained from close relatives
* Patient beneficiary of French social security, whatever the regime

Exclusion Criteria:

* Patient under 18 years old
* Patient with severe neutropenia (neutrophils \< 0.5 G/L)
* Patient under immunosuppressive treatment
* Use of corticosteroids (intravenous or oral) prior to ICU admission
* Use of therapeutic antibodies
* Onco-hematological disease (e.g. lymphoma, leukemia...) under treatment or treated in the 5 years prior to inclusion
* End of chemotherapy 6 months prior to inclusion
* Patients with innate or acquired immune deficiency (e.g., severe combined immunodeficiency, HIV or AIDS, at any stage)
* Patients with a decision to limit or discontinue active therapies, at the time of inclusion
* Patients with an estimated ICU stay of less than 48 hours
* Participation in an interventional study
* Patient deprived of their liberty
* Patient under tutorship or curatorship
* Pregnant or breastfeeding woman

Where it's running

• Centre Hospitalier Intercommunal Aix-Pertuis
  Aix-en-Provence, France Recruiting

Study contacts

• Principal investigator: Laurent LEFEBVRE, MD — Centre Hospitalier Intercommunal Aix-Pertuis
• Study coordinator: Laurent LEFEBVRE, MD
• Email: llefebvre@ch-aix.fr
• Phone: 0442335650

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.