Clinical trial Recruiting at 18 sites Interventional Ages 18 and up

Examining immune cell responses to teclistamab in multiple myeloma patients

Official title: Analysis of the Resistance and Sensitivity Mechanisms to Teclistamab by Focusing on Single Immune Cell Examination

Run by University Hospital, Toulouse · NCT05945524 · Data updated 2026-11-12

This study is testing how different immune cells in multiple myeloma patients respond to the treatment teclistamab to see why some people benefit from it while others do not.

More Multiple Myeloma trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity Hospital, Toulouse
Academic / other
Drugs / interventionsTeclistamab
Locations18 sites (Amiens, France and 17 other locations)
StatusRecruiting
StartedSeptember 28, 2023
Main results expectedMarch 31, 2026
Study endsMay 31, 2026
Registry record updatedApril 10, 2025
Trial IDNCT05945524 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients diagnosed with multiple myeloma who are receiving teclistamab and can provide informed consent.

Probably not a fit

Patients under legal protection may not benefit from this study due to exclusion criteria.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to analyze the immune and oncogenomic characteristics that differentiate patients with multiple myeloma who respond to teclistamab from those who exhibit resistance. By focusing on single immune cell examination, the research will investigate both phenotypic and genotypic traits associated with primary and secondary resistance to the treatment. Bone marrow samples will be collected from participants to facilitate this analysis. The findings could provide insights into personalized treatment strategies for multiple myeloma.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for multiple myeloma patients by identifying those most likely to benefit from teclistamab.

How similar studies have gone: While this approach is innovative, similar studies focusing on immune responses in cancer treatments have shown promise in identifying patient-specific treatment responses.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* With multiple myeloma
* Who receive Teclistamab
* Consent form signed

Exclusion Criteria:

* Patient under legal protection

Where it's running

  • CHU d'Amiens
    Amiens, France, France
    Recruiting
  • CHU de Caen
    Caen, France, France
    Recruiting
  • Polyclinique du Parc Drevon
    Dijon, France, France
    Recruiting
  • CH Annecy Genevois
    Epagny Metz- Tessy, France, France
    Recruiting
  • CHU de Lille
    Lille, France, France
    Recruiting
  • Centre Léon Bérard
    Lyon, France, France
    Recruiting
Show 12 more locations
  • CHU de Montpellier
    Montpellier, France, France
    Recruiting
  • Hôpital Saint-Louis
    Paris, France, France
    Recruiting
  • Hôpital Saint-Antoine
    Paris, France, France
    Recruiting
  • Hôpital Necker
    Paris, France, France
    Recruiting
  • CHU de Bordeaux
    Pessac, France, France
    Recruiting
  • CHU de Lyon
    Pierre-Bénite, France, France
    Recruiting
  • CHU de Poitiers
    Poitiers, France, France
    Recruiting
  • CHU de Rennes
    Rennes, France, France
    Recruiting
  • CH Saint-Etienne
    Saint-Priest-en-Jarez, France, France
    Recruiting
  • CHU de Toulouse
    Toulouse, France, France
    Recruiting
  • CHU de Tours
    Tours, France, France
    Recruiting
  • CHRU Nancy
    Vandœuvre-lès-Nancy, France, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.