Examining immune cell responses to teclistamab in multiple myeloma patients
Official title: Analysis of the Resistance and Sensitivity Mechanisms to Teclistamab by Focusing on Single Immune Cell Examination
Run by University Hospital, Toulouse · NCT05945524 · Data updated 2026-11-12
This study is testing how different immune cells in multiple myeloma patients respond to the treatment teclistamab to see why some people benefit from it while others do not.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital, Toulouse Academic / other |
| Drugs / interventions | Teclistamab |
| Locations | 18 sites (Amiens, France and 17 other locations) |
| Status | Recruiting |
| Started | September 28, 2023 |
| Main results expected | March 31, 2026 |
| Study ends | May 31, 2026 |
| Registry record updated | April 10, 2025 |
| Trial ID | NCT05945524 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with multiple myeloma who are receiving teclistamab and can provide informed consent.
✕Probably not a fit
Patients under legal protection may not benefit from this study due to exclusion criteria.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to analyze the immune and oncogenomic characteristics that differentiate patients with multiple myeloma who respond to teclistamab from those who exhibit resistance. By focusing on single immune cell examination, the research will investigate both phenotypic and genotypic traits associated with primary and secondary resistance to the treatment. Bone marrow samples will be collected from participants to facilitate this analysis. The findings could provide insights into personalized treatment strategies for multiple myeloma.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for multiple myeloma patients by identifying those most likely to benefit from teclistamab.
How similar studies have gone: While this approach is innovative, similar studies focusing on immune responses in cancer treatments have shown promise in identifying patient-specific treatment responses.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * With multiple myeloma * Who receive Teclistamab * Consent form signed Exclusion Criteria: * Patient under legal protection
Where it's running
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CHU d'Amiens
Amiens, France, France Recruiting -
CHU de Caen
Caen, France, France Recruiting -
Polyclinique du Parc Drevon
Dijon, France, France Recruiting -
CH Annecy Genevois
Epagny Metz- Tessy, France, France Recruiting -
CHU de Lille
Lille, France, France Recruiting -
Centre Léon Bérard
Lyon, France, France Recruiting
Show 12 more locations
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CHU de Montpellier
Montpellier, France, France Recruiting -
Hôpital Saint-Louis
Paris, France, France Recruiting -
Hôpital Saint-Antoine
Paris, France, France Recruiting -
Hôpital Necker
Paris, France, France Recruiting -
CHU de Bordeaux
Pessac, France, France Recruiting -
CHU de Lyon
Pierre-Bénite, France, France Recruiting -
CHU de Poitiers
Poitiers, France, France Recruiting -
CHU de Rennes
Rennes, France, France Recruiting -
CH Saint-Etienne
Saint-Priest-en-Jarez, France, France Recruiting -
CHU de Toulouse
Toulouse, France, France Recruiting -
CHU de Tours
Tours, France, France Recruiting -
CHRU Nancy
Vandœuvre-lès-Nancy, France, France Recruiting
Study contacts
- Principal investigator: Hervé AVET LOISEAU, MD, PhD — University Hospital, Toulouse
- Study coordinator: Hervé AVET LOISEAU, MD, PhD
- Email: avetloiseau.herve@iuct-oncopole.fr
- Phone: +33 531 156 142
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Tec Dara for newly diagnosed multiple myeloma with light chain amyloidosis
This study tests whether tec listamab plus daratumumab can help newly diagnosed multiple myeloma with AL amyloidosis and whether the combination is safe.
-
A comparison of JNJ-79635322 and teclistamab in relapsed or refractory multiple myeloma
This study tests whether JNJ-79635322 works differently from teclistamab in people with relapsed or refractory multiple myeloma who have had prior therapy.
-
Teclistamab plus mezigdomide for relapsed or refractory multiple myeloma
This trial will try a combination of teclistamab and mezigdomide in people with relapsed or refractory multiple myeloma who have had at least two prior therapies including a proteasome inhibitor, an IMiD, and an anti‑CD38 antibody.
-
Daratumumab followed by teclistamab with RVd for newly diagnosed multiple myeloma
This test tries whether switching from daratumumab plus RVd to teclistamab plus RVd after three treatment cycles is safe for people with newly diagnosed multiple myeloma.
-
T-cell therapies talquetamab and teclistamab to clear minimal residual disease after transplant in newly diagnosed myeloma (ROTATE)
This tests whether giving talquetamab to patients who are MRD positive after induction and transplant, and switching to teclistamab if MRD doesn't clear, can make them MRD negative.
-
Using bispecific T-cell redirectors for first-line treatment in transplant-eligible multiple myeloma patients
This study is testing if a new combination of treatments can help newly diagnosed multiple myeloma patients who are eligible for a stem cell transplant feel better and improve their outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.