Examining how well Aronia Melanocarpa is absorbed in the body
Evaluating Kinetics and Bioavailability of Aronia Melanocarpa Extract in Healthy Young and Older Adults
This study tests how well a drink made from Aronia Melanocarpa is absorbed by the body in healthy young adults and older adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Maastricht University Medical Center Academic / other |
| Locations | 1 site (Maastricht) |
| Trial ID | NCT06306911 on ClinicalTrials.gov |
What this trial studies
This study investigates the bioavailability and kinetics of Aronia Melanocarpa extract supplementation in both healthy young adults aged 18-35 and older adults aged 55-75. Participants will consume a drink containing the extract, and researchers will monitor its absorption and metabolism through blood, urine, and fecal samples collected at various intervals. The goal is to quantify the profiles of the extract and its metabolites to understand how effectively the body utilizes this supplement.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-35 or 55-75 with a stable body weight and no severe medical conditions.
Not a fit: Patients with severe medical conditions, those on specific medications, or individuals with a history of substance abuse may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the health benefits of Aronia Melanocarpa and its effectiveness as a dietary supplement.
How similar studies have performed: While studies on the health benefits of Aronia Melanocarpa exist, this specific investigation into its bioavailability and kinetics is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI between 18-35 kg/m2 * Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 100 mmHg * Stable body weight (weight gain or loss \< 3 kg in the past three months) * Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study Exclusion Criteria: * Smoking or smoking cessation \< 12 months * Severe medical conditions, including asthma, kidney failure, auto-inflammatory diseases, rheumatoid arthritis, diabetes mellitus, cardiovascular disease, gastrointestinal disorders such as Crohn's disease, colitis * Use of dietary supplements or medication affecting the main outcomes of the study (e.g. affecting gut metabolism, blood pressure medication) * Use of an investigational product within another biomedical intervention trial within the previous month * Abuse of drugs * More than 3 alcoholic consumptions per day * Known pregnancy or lactation * Known allergy to study product * Difficult venepuncture
Where this trial is running
Maastricht
- Maastricht University — Maastricht, Netherlands (Recruiting)
Study contacts
- Principal investigator: Jogchum Plat, Prof — Maastricht University
- Study coordinator: Sanne Ahles, Msc
- Email: s.ahles@maastrichtuniversity.nl
- Phone: +31437114555
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.