Examining how telomere biology and sperm DNA fragmentation affect embryonic development
Impact of Telomere Biology and Sperm DNA Fragmentation on Embryonic Development
This study is testing how telomere length and sperm DNA damage might affect fertility in men who are struggling to conceive without a known reason.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 204 (estimated) |
| Sex | Male |
| Sponsor | IVI Madrid Academic / other |
| Locations | 1 site (Madrid) |
| Trial ID | NCT05508217 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the role of telomere biology and sperm DNA fragmentation in male infertility. It will involve men attending a fertility clinic who do not have a known cause for their infertility. Various analyses will be conducted, including measuring telomere length using Q-FISH and PCR, assessing sperm DNA fragmentation through the tunnel technique, and evaluating sperm maturation. The study will correlate these factors with age, sperm quality, and pregnancy outcomes to identify potential predictors of male fertility.
Who should consider this trial
Good fit: Ideal candidates include men of any age with normozoospermia attending a fertility clinic.
Not a fit: Patients with known chronic diseases or genetic alterations may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into male fertility and help develop predictive tools for assessing fertility potential.
How similar studies have performed: While the specific approach may be novel, studies examining sperm DNA fragmentation and telomere length have shown promising results in understanding male fertility.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men of any age who come to IVI Madrid in the context of a couple's infertility study and who present normozoospermia or semenograms with sperm count \>10mill/ml, \>25% progressive motility and \> 1% normal morphology. Exclusion Criteria: * Males who have suffered any acute illness in the three months prior to inclusion in the study. * Males with any known chronic disease or genetic alteration.
Where this trial is running
Madrid
- Ivirma Madrid — Madrid, Spain (Recruiting)
Study contacts
- Principal investigator: Carlos Balmori Boticario, PhD — IVI Madrid
- Study coordinator: Carlos Balmori Boticario, PhD
- Email: Carlos.Balmori@ivirma.com
- Phone: +34 180 29 00
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.