Examining how stress and diet affect metabolism
Multi-level Molecular Profiling of Stress Exposure Under Standardized Food Intake: A Clinical Study
NA · University Hospital, Bonn · NCT06016530
This study is testing how stress and diet affect metabolism in healthy women by looking at their blood after a lack of sleep and a specific treatment.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | University Hospital, Bonn (other) |
| Locations | 1 site (Bonn, North Rhine-Westphalia) |
| Trial ID | NCT06016530 on ClinicalTrials.gov |
What this trial studies
This clinical study investigates the interaction between nutrition and stress by analyzing blood components in healthy volunteers during a standardized diet. Participants will undergo a baseline measurement followed by a 36-hour sleep deprivation to induce physiological stress, and then receive dexamethasone as a pharmacological stressor. The study aims to utilize a multi-omics approach to understand the molecular processes involved in nutrition and stress, particularly focusing on hormonal influences in female participants. The findings could enhance our understanding of nutritional physiology and its implications for clinical practice.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals aged 18 to 30 with a BMI between 18 and 30.
Not a fit: Patients with a history of neurological conditions, hormonal contraception use, or cardiovascular diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how dietary interventions can mitigate the effects of stress on metabolism, potentially improving treatment strategies for stress-related disorders.
How similar studies have performed: While there is existing observational research on nutrition and stress, this study's multi-omics approach is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Present written declaration of consent * Healthy * BMI between 18 and 30 Exclusion Criteria: * Insufficient linguistic communication * Drug abuse or alcohol dependency * Smoker * Hormonal contraception * Neurological condition or epilepsy in the medical history * Regular medication except for L-thyroxine or antihistamines * A known disease of the cardiovascular system, hypertension higher than 160/90mmHg
Where this trial is running
Bonn, North Rhine-Westphalia
- University Hospital Bonn, Department of Psychiatry and Psychotherapy — Bonn, North Rhine-Westphalia, Germany (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stress Related Disorder, Nutrition, Healthy, Metabolism, Stress Related Disorders, Nutrition