Examining how sex affects tolerance to changes in gravity during lunar conditions
Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent
This study is testing how men and women react differently to changes in gravity, like those on the moon, to see if a special compression garment can help improve their blood flow and reduce symptoms of dizziness.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 38 (estimated) |
| Ages | 25 Years to 55 Years |
| Sex | All |
| Sponsor | National Aeronautics and Space Administration (NASA) Federal |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT06467825 on ClinicalTrials.gov |
What this trial studies
This study investigates the differences in orthostatic intolerance and cardiovascular responses between males and females when subjected to varying angles of head-up tilt that simulate lunar gravity conditions. It consists of two phases: the first phase assesses the development of orthostatic intolerance symptoms in participants, while the second phase evaluates the impact of a custom-made lower-body compression garment on these responses. Participants will undergo detailed measurements and monitoring during tilt tests to gather data on their cardiovascular responses. The study aims to enhance our understanding of how sex influences physiological responses in space-like environments.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy males and females who meet specific physical screening criteria.
Not a fit: Patients with systemic diseases, renal disease, or those currently taking medications that interact adversely with furosemide may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve safety and health protocols for astronauts during lunar missions by tailoring interventions based on sex differences.
How similar studies have performed: While studies on orthostatic intolerance exist, this specific approach examining sex differences in a lunar context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Pass a test subject screening facility modified Air Force Class III physical Exclusion Criteria: * Known allergy to furosemide or sulfa drugs * Currently taking drugs or medications known to adversely interact with furosemide, including but not limited to aspirin, NSAIDs, antibiotics, or immunosuppressant drugs * Systemic diseases or current medications known to influence the cardiovascular system * Renal disease * Type II Diabetes * Pregnant participants will be excluded (a urine pregnancy screen will be made available).
Where this trial is running
Houston, Texas
- Nasa — Houston, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Jason R Lytle, PhD
- Email: jsc-cardilab@mail.nasa.gov
- Phone: 281-483-9531
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.