Examining how sex affects tolerance to changes in gravity during lunar conditions
Official title: Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent
Run by National Aeronautics and Space Administration (NASA) · NCT06467825 · Data updated 2026-11-12
This study is testing how men and women react differently to changes in gravity, like those on the moon, to see if a special compression garment can help improve their blood flow and reduce symptoms of dizziness.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 55 Years |
| Sex | All |
| Enrollment | 38 (estimated) |
| Sponsor | National Aeronautics and Space Administration (NASA) Federal |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | August 9, 2022 |
| Main results expected | September 2025 |
| Study ends | September 2025 |
| Registry record updated | April 1, 2025 |
| Trial ID | NCT06467825 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy males and females who meet specific physical screening criteria.
✕Probably not a fit
Patients with systemic diseases, renal disease, or those currently taking medications that interact adversely with furosemide may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the differences in orthostatic intolerance and cardiovascular responses between males and females when subjected to varying angles of head-up tilt that simulate lunar gravity conditions. It consists of two phases: the first phase assesses the development of orthostatic intolerance symptoms in participants, while the second phase evaluates the impact of a custom-made lower-body compression garment on these responses. Participants will undergo detailed measurements and monitoring during tilt tests to gather data on their cardiovascular responses. The study aims to enhance our understanding of how sex influences physiological responses in space-like environments.
Why it matters
Potential benefit: If successful, this study could improve safety and health protocols for astronauts during lunar missions by tailoring interventions based on sex differences.
How similar studies have gone: While studies on orthostatic intolerance exist, this specific approach examining sex differences in a lunar context is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: • Pass a test subject screening facility modified Air Force Class III physical Exclusion Criteria: * Known allergy to furosemide or sulfa drugs * Currently taking drugs or medications known to adversely interact with furosemide, including but not limited to aspirin, NSAIDs, antibiotics, or immunosuppressant drugs * Systemic diseases or current medications known to influence the cardiovascular system * Renal disease * Type II Diabetes * Pregnant participants will be excluded (a urine pregnancy screen will be made available).
Where it's running
-
Nasa
Houston, Texas, United States Recruiting
Study contacts
- Study coordinator: Jason R Lytle, PhD
- Email: jsc-cardilab@mail.nasa.gov
- Phone: 281-483-9531
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.