Examining how myopia treatments affect eye shape
Longitudinal Changes in Eye Shape in Young Adults Treated With Low-Dose Atropine and Soft Multifocal Contact Lenses
This study is testing if low-dose atropine eye drops or special contact lenses can change the shape of the eyes in young adults with nearsightedness to help manage their condition better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 21 Years to 30 Years |
| Sex | All |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT06450132 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of low-dose atropine eye drops and soft multifocal contact lenses on the shape of the peripheral eye in nearsighted young adults. Participants will be randomly assigned to either use the eye drops nightly, wear special contact lenses daily, or receive no intervention. Over the course of 12 months, they will undergo multiple eye examinations, including prescription checks and health assessments, while researchers analyze changes in eye shape and focusing system responses. The study aims to determine if these interventions can effectively alter eye shape and improve myopia management.
Who should consider this trial
Good fit: Ideal candidates are nearsighted young adults who currently wear contact lenses and have good visual acuity.
Not a fit: Patients with eye diseases, those who are pregnant or nursing, or individuals with a history of refractive surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for managing myopia in young adults.
How similar studies have performed: Other studies have shown promising results with similar interventions for myopia management, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * best corrected visual acuity of 20/25 or better in each eye * nearsighted * current contact lens wearer * normal binocular vision (to be determined by an examiner at the first study visit) Exclusion Criteria: * eye diseases (including lazy eye or eye turn) * pregnant, nursing, or planning a pregnancy in the next 12 months * history of refractive surgery (e.g., LASIK) * history of myopia control treatment * sensitivity to anesthetics or preservative in eye drops * difficulty with pupillary dilation
Where this trial is running
Columbus, Ohio
- The Ohio State University — Columbus, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Donald O Mutti, OD, PhD — Ohio State University
- Study coordinator: Marielle G Reidy, OD, MS
- Email: reidy.39@osu.edu
- Phone: 614-688-0028
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.