Examining how lung cancer lesions shrink after radiotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze the regression patterns of primary lung cancer lesions following definitive radiotherapy. By retrospectively collecting clinical data from patients who have undergone this treatment, the study will utilize imaging tools to measure changes in tumor size and volume. The goal is to establish a model for tumor regression and evaluate the relationship between regression rates, adverse effects, and patient prognosis. This research seeks to optimize radiotherapy plans to enhance treatment efficacy for lung cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years old;
2. Stage II-III lung cancer with a clear pathological diagnosis report or medical record, not undergoing surgery before radiotherapy;
3. The primary lung lesion received definitive radiotherapy (defined as conventional fractionation radiotherapy with dose ≥50Gy, stereotactic radiotherapy with biologically effective dose ≥100Gy);
4. The target lesion of the lung receiving radiotherapy can be measured;
5. Imaging data can be obtained before and after radiotherapy;
6. Complete radiotherapy as planned, or the actual received dose has reached the defined definitive dose.

Exclusion Criteria：

1. Before radiotherapy, the primary lesion of the lung had received local treatment such as surgery or ablative treatment;
2. The radiotherapy plan was not completed, and the actual dose received did not reach the definitive dose (defined as conventional fractionation radiotherapy with dose \<50Gy, stereotactic radiotherapy with biologically effective dose \<100Gy)；
3. Required imaging data cannot be obtained;
4. Other conditions considered by the investigator to be inappropriate for enrollment.

Where it's running

• China-Japan Friendship Hospital
  Beijing, Beijing Municipality, China Recruiting
• Renmin Hospital of Wuhan University
  Wuhan, Hubei, China Recruiting

Study contacts

• Principal investigator: Guangying Zhu, M.D. — China-Japan Friendship Hospital
• Study coordinator: Guangying Zhu, M.D.
• Email: zryyfa@163.com
• Phone: +86 010-84205380

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.