Examining how gut bacteria and vitamin D affect allergic diseases in infants
Official title: The Roles of Human Microbiome and Vitamin D in the Development of Childhood Allergic Diseases
Run by China Medical University Hospital · NCT05670262 · Data updated 2026-11-12
This study is trying to see how gut bacteria and vitamin D levels affect the chances of infants developing allergic diseases like asthma and eczema in their first year of life.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years to 1 Year |
| Sex | All |
| Enrollment | 6000 (estimated) |
| Sponsor | China Medical University Hospital Academic / other |
| Locations | 1 site (Taichung) |
| Status | Recruiting |
| Started | August 4, 2022 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | February 7, 2024 |
| Trial ID | NCT05670262 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are term newborn babies born at China Medical University Hospital.
✕Probably not a fit
Patients who are premature, have congenital anomalies, or require immediate resuscitation after birth may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational birth cohort study aims to evaluate the influence of the human microbiome and vitamin D on the development of allergic diseases in infants under one year of age. It focuses on understanding how genetic and environmental factors, particularly early exposure to allergens and microbes, contribute to conditions like atopic dermatitis, allergic rhinitis, and asthma. The study will assess the relationship between vitamin D levels, vitamin D binding protein, and gut microbiota colonization in newborns. By analyzing these factors, the researchers hope to uncover the mechanisms behind the increasing prevalence of allergic diseases in young children.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing allergic diseases in infants.
How similar studies have gone: While the role of the microbiome and vitamin D in allergic diseases has been explored, this specific birth cohort approach is relatively novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All term newborn babies who are born in China Medical University Hospital. The term baby defines the maternal gestational age between 37 0/7 weeks to 41 6/7 weeks. Exclusion Criteria: * The exclusion criteria are prematurity newborn, congenital anomalies and cardiopulmonary failure need for resuscitation immediately after birth.
Where it's running
-
China Medical University Hospital
Taichung, Taiwan Recruiting
Study contacts
- Study coordinator: Jiu-Yao Wang, MD
- Email: aim.cmuh@gmail.com
- Phone: 886422052121
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.