Examining how gut bacteria and vitamin D affect allergic diseases in infants

The Roles of Human Microbiome and Vitamin D in the Development of Childhood Allergic Diseases

This study is trying to see how gut bacteria and vitamin D levels affect the chances of infants developing allergic diseases like asthma and eczema in their first year of life.

Quick facts

• Study type: Observational
• Enrollment: 6000 (estimated)
• Ages: 0 Years to 1 Year
• Sex: All
• Sponsor: China Medical University Hospital (other)
• Locations: 1 site (Taichung)
• Trial ID: NCT05670262 on ClinicalTrials.gov

What this trial studies

This observational birth cohort study aims to evaluate the influence of the human microbiome and vitamin D on the development of allergic diseases in infants under one year of age. It focuses on understanding how genetic and environmental factors, particularly early exposure to allergens and microbes, contribute to conditions like atopic dermatitis, allergic rhinitis, and asthma. The study will assess the relationship between vitamin D levels, vitamin D binding protein, and gut microbiota colonization in newborns. By analyzing these factors, the researchers hope to uncover the mechanisms behind the increasing prevalence of allergic diseases in young children.

Who should consider this trial

Good fit: Ideal candidates for this study are term newborn babies born at China Medical University Hospital.

Not a fit: Patients who are premature, have congenital anomalies, or require immediate resuscitation after birth may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for preventing allergic diseases in infants.

How similar studies have performed: While the role of the microbiome and vitamin D in allergic diseases has been explored, this specific birth cohort approach is relatively novel and untested.

Eligibility criteria

Inclusion Criteria:

* All term newborn babies who are born in China Medical University Hospital. The term baby defines the maternal gestational age between 37 0/7 weeks to 41 6/7 weeks.

Exclusion Criteria:

* The exclusion criteria are prematurity newborn, congenital anomalies and cardiopulmonary failure need for resuscitation immediately after birth.

Where this trial is running

Taichung

• China Medical University Hospital — Taichung, Taiwan (RECRUITING)

Study contacts

• Study coordinator: Jiu-Yao Wang, MD

Conditions: Pediatric, allergic diseases, birth cohort, human microbiome, vitamin D, vitamin D receptors and vitamin D binding protein