Examining how gum inflammation affects healing after tooth extraction
Association of Periodontal Inflammation on Immune Response in Wound Healing
This study is trying to see how gum inflammation affects the healing process after people have a tooth pulled.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 21 Years to 70 Years |
| Sex | All |
| Sponsor | University of Nebraska Academic / other |
| Locations | 1 site (Lincoln, Nebraska) |
| Trial ID | NCT04805320 on ClinicalTrials.gov |
What this trial studies
This observational study will recruit 25 healthy adults aged 21-70 who require the extraction of a posterior tooth. Before the extraction, various clinical markers of periodontal inflammation, body mass index, and dental radiographs will be assessed. The tooth will be extracted atraumatically, and soft tissue biopsies will be taken from the extraction site at both two weeks and three months post-operation to analyze the immune response during wound healing. The study aims to understand the relationship between periodontal inflammation and the healing process following dental procedures.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 21-70 with a non-restorable posterior tooth requiring extraction.
Not a fit: Patients with systemic diseases that affect inflammation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of how periodontal inflammation impacts wound healing, potentially leading to improved dental care practices.
How similar studies have performed: While there is ongoing research into the effects of periodontal health on healing, this specific approach of examining immune responses through biopsies post-extraction is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * non-restorable posterior tooth (molar/premolar) in need of extraction Exclusion Criteria: * systemic disease that effects inflammation
Where this trial is running
Lincoln, Nebraska
- University of Nebraska, College of Dentistry — Lincoln, Nebraska, United States (Recruiting)
Study contacts
- Study coordinator: Amy C Killeen, DDS
- Email: akilleen@unmc.edu
- Phone: 402-472-7848
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.