Examining how glucose variability affects cognition in prediabetes
Relations of Glucose Variability with Cognitive Function and Functional Status Among Older Adults At Risk for Diabetes
This study looks at how changes in blood sugar levels might affect thinking and memory in people over 50 who are at risk for diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT04201600 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between fluctuations in glucose levels and cognitive function in individuals aged 50 and older who are at risk for diabetes. Participants will wear a continuous glucose monitoring device for 10 days while their cognitive and functional status is assessed through two study visits. The study aims to determine if glucose variability is linked to cognitive decline and functional impairment before the onset of diabetes. By utilizing advanced monitoring technology, the researchers hope to uncover important insights into the effects of glucose on neurocognition.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 50 years and older with prediabetes who do not have a diagnosis of diabetes.
Not a fit: Patients with diagnosed type 1 or type 2 diabetes or those with significant chronic or neurological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive decline in individuals with prediabetes.
How similar studies have performed: While the relationship between glucose levels and cognitive function has been explored, this specific approach using continuous glucose monitoring in prediabetic individuals is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 50 years and older * At least 8th grade education Exclusion Criteria: * Diagnosed type 1 or type 2 diabetes * Current use of mediation for diabetes (oral hypoglycemic agents, insulin), or with diabetic properties (e.g., steroids) * Chronic disorders (cardiovascular disease, peripheral vascular disease, stroke, transient ischemic attack, chronic kidney disease, past year cancer) * Neurological disorders (e.g., Parkinson's, epilepsy, multiple sclerosis) * History of dementia or suspected dementia * Known HIV * Serious mental illness, psychosis, or use of psychotropic medication * Heavy alcohol use
Where this trial is running
Baltimore, Maryland
- Baltimore VA Geriatric Research Education and Clinical Center (GRECC) — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Tasneem Khambaty, PhD — University of Maryland, Baltimore County
- Study coordinator: Kathleen Simpson
- Email: Kathleen.Simpson@va.gov
- Phone: 4106057179
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.