Examining how exercise affects glucose uptake in people with upper body obesity

Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

This study tests how exercise affects how well people with upper body obesity use sugar in their bodies.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 48 (estimated)
• Ages: 18 Years to 55 Years
• Sex: All
• Sponsor: Mayo Clinic (Academic / other)
• Locations: 1 site (Rochester, Minnesota)
• Trial ID: NCT04532814 on ClinicalTrials.gov

What this trial studies

This study investigates the relationship between muscle insulin action and exercise-induced glucose uptake in individuals with upper body obesity. It aims to explore this interaction from a whole-body perspective down to the cellular and molecular levels. Participants will engage in exercise interventions to assess how their bodies respond in terms of glucose metabolism. The study includes both insulin-sensitive and insulin-resistant groups to provide a comprehensive understanding of these mechanisms.

Who should consider this trial

Good fit: Ideal candidates include premenopausal women and age-matched men who are upper body obese and weight stable for at least two months.

Not a fit: Patients under 18 or over 55 years old, those using glucose-lowering agents, or with a history of certain medical conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved exercise recommendations and interventions for individuals with upper body obesity, enhancing their metabolic health.

How similar studies have performed: Other studies have shown success in examining exercise effects on glucose metabolism, but this specific focus on upper body obesity is relatively novel.

Eligibility criteria

Inclusion Criteria:

For the exercise studies of leg glucose uptake - "insulin sensitive" group:

* Sedentary, normal weight, premenopausal women.
* Sedentary, age-matched normal weight men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.
* For the exercise studies of leg glucose uptake - "insulin resistant" group:

For the exercise studies of leg glucose uptake - "insulin resistant" group:

* Upper body obese (UBO) premenopausal women.
* Age-matched upper body obese (UBO) men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.

Exclusion Criteria:

* Age \< 18 or \> 55 years (premenopausal women and age-matched men).
* Use of glucose-lowering agents.
* For female subjects: positive pregnancy test at the time of enrollment or study
* History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
* Active systemic illness or malignancy.
* Symptomatic macrovascular or microvascular disease.

Where this trial is running

Rochester, Minnesota

• Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)

Study contacts

• Principal investigator: Michael D Jensen, MD — Mayo Clinic
• Study coordinator: Madeline Reid

Conditions Upper Body Obesity