Examining how endoscopic ultrasound affects treatment decisions in oesophageal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the role of endoscopic ultrasound (EUS) in managing patients with oesophageal cancer. It aims to determine how often EUS alters treatment decisions after initial staging with CT and PET-CT. The study includes both quantitative and qualitative components, assessing the frequency of changes in management and exploring clinician and patient perspectives on EUS's utility. The trial will recruit patients with potentially curable disease who are fit for EUS as part of their standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged 16 or above with first diagnosis of biopsy-confirmed oesophageal cancer.
2. Referred for EUS examination as part of standard of care investigations.
3. Tumour location in the oesophagus, or gastro-oesophageal junction (Siewert types I-III)
4. MDT decision that patient is potentially curable with radical treatment (e.g., endoscopic treatment, surgery +/- neoadjuvant therapy, or definitive chemoradiotherapy)
5. Prior staging with CT and PET-CT
6. Eastern Cooperative Oncology Group (ECOG) performance status 0-2
7. Clinical staging of T1-T4, N0-N3, M0 disease
8. Adenocarcinoma or squamous cell carcinoma (SCC) histopathological cell type

   Exclusion Criteria:
9. Recurrent or residual disease
10. Distant metastatic disease detected before EUS.
11. Previous oesophagectomy or oesophageal radiotherapy
12. Unable to undergo EUS examination.
13. Concurrent malignancy e.g., second primary tumour
14. Other histopathological cell type

Where it's running

• Cwm Taf UHB
  Abercynon, United Kingdom Recruiting
• Cambridge University NHS Foundation Trust
  Cambridge, United Kingdom Recruiting
• Cardiff and Vale UHB
  Cardiff, United Kingdom Recruiting
• Velindre University NHS Trust
  Cardiff, United Kingdom Recruiting
• Glasgow Royal Infirmary
  Glasgow, United Kingdom Recruiting
• Castle Hill Hospital
  Hull, United Kingdom Recruiting

Study contacts

• Principal investigator: Kieran Foley — Chief Investigator, based at Velindre University NHS Trust
• Study coordinator: Ben Lindfield
• Email: value@soton.ac.uk
• Phone: 023 8120 5154

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Seismocardiography to gauge fitness and predict outcomes before esophageal cancer surgery

  A noninvasive seismocardiography device is tested to see if it can quickly estimate a patient’s fitness and help predict surgical outcomes for adults with esophageal cancer who are planning curative treatment.

  Recruiting at 3 sites Guy's and St Thomas' NHS Foundation Trust · Guildford and 3 other locations · NCT07159711

• Pulsed low-dose-rate radiation plus chemotherapy versus standard chemoradiation for esophageal cancer

  This trial will test whether delivering radiation as pulsed low-dose-rate together with chemotherapy reduces serious esophagitis compared with standard chemoradiation in adults with locally advanced esophageal adenocarcinoma.

  Recruiting Phase 2 Medical College of Wisconsin · Milwaukee, Wisconsin · NCT06906887

• Using a new imaging technique to detect cancer-associated fibroblasts in various cancers

  This study is testing a new imaging method to see if it can better detect certain cancer-related cells in people with newly diagnosed esophageal or pancreatic cancer compared to standard imaging techniques.

  Recruiting at 2 sites Phase 2/3 KU Leuven · Edegem and 2 other locations · NCT06782412

• Analyzing shopping habits to improve early cancer diagnosis

  This study is trying to see if changes in shopping habits can help spot cancer earlier by looking at purchase data from loyalty cards of people recently diagnosed with cancer and those without it.

  Recruiting Imperial College London · London · NCT06447064

• Reducing dosing frequency of immune checkpoint inhibitors in advanced cancers

  This study is testing if giving immune checkpoint inhibitors less often can still help people with advanced cancers feel better while making treatment easier and cheaper.

  Recruiting Phase 2 National University Hospital, Singapore · Singapore · NCT06422403

• New self-expandable metal stent to relieve malignant esophageal strictures

  This test will try a new self-expandable metal stent to relieve swallowing problems in adults with incurable esophageal cancer.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT06364553

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.