Examining how different foods affect metabolism in older and younger men
Metabolic Availability of Three Protein Sources in Older and Younger Men as Measured With the Indicator Amino Acid Oxidation Method
This study is testing how different foods like black beans, sorghum, and milk affect metabolism in younger and older men to see if age makes a difference.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 28 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | Male |
| Sponsor | Wageningen University Academic / other |
| Locations | 1 site (Wageningen, Gelderland) |
| Trial ID | NCT06332651 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the metabolic availability of specific amino acids found in black beans, sorghum, and milk in both older and younger male participants. Using the indicator amino acid oxidation method, the research will compare how these foods are metabolized across different age groups. The study will include healthy males aged 20-35 and 65-80, ensuring they meet specific health criteria and dietary habits. Participants will be monitored to ensure compliance with study procedures and data collection.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy males aged 20-35 or 65-80 with a BMI between 18.5 and 30.0.
Not a fit: Patients with chronic diseases such as diabetes, severe cardiovascular issues, or any gastrointestinal disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of nutritional needs and metabolic processes in aging men, potentially leading to improved dietary recommendations.
How similar studies have performed: While studies on amino acid metabolism exist, this specific approach comparing age groups with these particular foods is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Gender: Male Age: 20-35 years or 65-80 years Body Mass Index (BMI): 18.5 - 30.0 kg/m2 Healthy as assessed with a questionnaire Regular and normal eating habits as assessed with a Food Frequency Questionnaire (FFQ) Willing to comply with study procedures and use of data Having given written informed consent Exclusion Criteria: Chronic disease, for example: * Diabetes mellitus / being treated for high blood glucose * Severe cardiovascular disease (exception: hypertension) * Hepatic disease (e.g. hepatitis) * Renal disease * Cancer * Bowel disease (e.g. inflammatory bowel disease, ulcers, bleeding) * Pancreatitis History of medical or surgical events that may affect GI function, and the study outcomes or disease risk for participants, for example: * Bariatric surgery * Gastrointestinal tract surgery * Digestive tract disorder * Chewing problems * History of deep venous thrombosis without anti-coagulation medication Medicine use that interferes with, protein metabolism, GI function and the study outcomes, for example: * Glucose lowering drugs * Proton pump inhibitors * Laxatives Habits that interfere with the study outcomes: * Protein supplement use (current use or less than 2 weeks past use) * Smoking * Drug use * Alcohol consumption \>21 units/week and/or \>4/day * Following a weight-loss diet, medically prescribed diet or other diet with a low calorie intake or an unbalanced nutrient intake like a vegan or very low carbohydrate diet * Moderate to high intense physical activity for more than 5 hours a week Other: * Self-reported allergy or intolerance to the tested products * Weight loss of more than 3 kg in the 3 months prior to study screening * Current participation in other research and \<2 months prior participation in other research * Not having a general practitioner * Not willing to accept information-transfer concerning participation in the study , or information regarding his health to his general practitioner * Working or doing an MSc- thesis at the department of Human Nutrition and Health at Wageningen University \& Research
Where this trial is running
Wageningen, Gelderland
- Wageningen University & Research — Wageningen, Gelderland, Netherlands (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.