Examining how different foods affect metabolism in older and younger men

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the metabolic availability of specific amino acids found in black beans, sorghum, and milk in both older and younger male participants. Using the indicator amino acid oxidation method, the research will compare how these foods are metabolized across different age groups. The study will include healthy males aged 20-35 and 65-80, ensuring they meet specific health criteria and dietary habits. Participants will be monitored to ensure compliance with study procedures and data collection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Gender: Male Age: 20-35 years or 65-80 years Body Mass Index (BMI): 18.5 - 30.0 kg/m2 Healthy as assessed with a questionnaire Regular and normal eating habits as assessed with a Food Frequency Questionnaire (FFQ) Willing to comply with study procedures and use of data Having given written informed consent

Exclusion Criteria:

Chronic disease, for example:

* Diabetes mellitus / being treated for high blood glucose
* Severe cardiovascular disease (exception: hypertension)
* Hepatic disease (e.g. hepatitis)
* Renal disease
* Cancer
* Bowel disease (e.g. inflammatory bowel disease, ulcers, bleeding)
* Pancreatitis

History of medical or surgical events that may affect GI function, and the study outcomes or disease risk for participants, for example:

* Bariatric surgery
* Gastrointestinal tract surgery
* Digestive tract disorder
* Chewing problems
* History of deep venous thrombosis without anti-coagulation medication

Medicine use that interferes with, protein metabolism, GI function and the study outcomes, for example:

* Glucose lowering drugs
* Proton pump inhibitors
* Laxatives

Habits that interfere with the study outcomes:

* Protein supplement use (current use or less than 2 weeks past use)
* Smoking
* Drug use
* Alcohol consumption \>21 units/week and/or \>4/day
* Following a weight-loss diet, medically prescribed diet or other diet with a low calorie intake or an unbalanced nutrient intake like a vegan or very low carbohydrate diet
* Moderate to high intense physical activity for more than 5 hours a week

Other:

* Self-reported allergy or intolerance to the tested products
* Weight loss of more than 3 kg in the 3 months prior to study screening
* Current participation in other research and \<2 months prior participation in other research
* Not having a general practitioner
* Not willing to accept information-transfer concerning participation in the study , or information regarding his health to his general practitioner
* Working or doing an MSc- thesis at the department of Human Nutrition and Health at Wageningen University \& Research

Where it's running

• Wageningen University & Research
  Wageningen, Gelderland, Netherlands Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.