Examining how biological sex affects heart function in CTEPH patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify differences in right ventricular (RV) function between biological sexes in patients diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH). It will analyze historical data from patients who have undergone right heart catheterization and echocardiography to assess RV function at diagnosis and after pulmonary thromboendarterectomy (PTE) surgery. The study will also explore the relationship between sex hormone levels and RV function during diagnosis and recovery. The methodology includes TTE strain analysis to compare RV function across sexes.

Why it matters

Who can join: the full rules

Inclusion criteria

* Adult (≥18 years old) patients diagnosed with CTEPH per current guideline standard42
* Subject must have a baseline TTE (within 3 months of diagnosis) with adequate images for RVGLS analysis
* Subject must have a right heart catheterization (RHC) at the time of diagnosis
* To be included in the Aim 2 analysis, patients must undergo PTE surgery and have a TTE performed 3-9 months after surgery with adequate images for RVGLS strain analysis

Exclusion criteria

* Unclear or mixed PH diagnosis as designated by an expert clinician at Intermountain PH center
* Any subjects \<18 years of age
* Patients diagnosed during pregnancy
* Patients without a TTE and RHC at time of diagnosis

Where it's running

• Intermountain Medical Center
  Murray, Utah, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.