Examining gut permeability changes in normal-weight obesity after exercise
Indicators of Gut Permeability in Normal-weight Obesity in Response to Brief, Maximal and Sustained, Submaximal Exercise
NA · Oklahoma State University · NCT05889767
This study is testing how different types of exercise affect gut health in people with normal-weight obesity compared to those with normal weight and those with obesity.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Oklahoma State University (other) |
| Locations | 1 site (Stillwater, Oklahoma) |
| Trial ID | NCT05889767 on ClinicalTrials.gov |
What this trial studies
This study investigates how exercise affects gut permeability in individuals with normal-weight obesity compared to those with normal body weight and those with obesity. Participants will undergo two types of exercise tests: a short, intense VO2 max test and a sustained moderate exercise session. The study aims to measure serum indicators of gut permeability and other health metrics before and after these exercise interventions. By understanding these responses, the research seeks to shed light on the relationship between exercise and gut health in at-risk populations.
Who should consider this trial
Good fit: Ideal candidates include individuals with normal-weight obesity, defined as having a normal BMI but a high body fat percentage.
Not a fit: Patients with established cardiometabolic diseases or those who are pregnant or postmenopausal may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how exercise can improve gut health and inflammation in individuals with normal-weight obesity.
How similar studies have performed: While the specific focus on normal-weight obesity and exercise-induced gut permeability is novel, related studies have shown that exercise can influence gut health in various populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Control group: normal BMI, body fat percentage \< 25% (male) or \< 35% (female) Normal-weight obesity: normal BMI, body fat percentage \> 25% (male) or \> 35% (female) Overt obesity: BMI in obesity range, body fat percentage \> 25% (male) or \> 35% (female) Exclusion Criteria: * Presence of pacemaker * Pregnant * Postmenopausal status * History of chronically using of tobacco products, illicit drugs, anti-inflammatory drugs (e.g., NSAIDs), lipid lowering drugs * Recent use of antibiotics (\< 6 weeks) and NSAIDs (\< 3 days) * Established cardiometabolic disease (e.g., cardiovascular disease, type 2 diabetes) diseases inflammatory in nature (e.g., rheumatoid arthritis, inflammatory bowel disease), and/or diagnosed irritable bowel syndrome.
Where this trial is running
Stillwater, Oklahoma
- 208 Nancy Randolph Davis, Oklahoma State University — Stillwater, Oklahoma, United States (RECRUITING)
Study contacts
- Study coordinator: Bryant H Keirns, MS
- Email: bryant.keirns@okstate.edu
- Phone: 3166891711
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Normal-weight Obesity, Obesity