Examining gut microbiota markers in patients with Sjögren's syndrome
Descriptive Study of Variations in Serum Translocation Markers of the Intestinal Microbiota in Patients With Gougerot-Sjögren Syndrome According to Disease Activity
Centre Hospitalier Universitaire de Nīmes · NCT04462601
This study is trying to see how changes in gut bacteria might affect the symptoms of Sjögren's syndrome in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nīmes (other) |
| Locations | 1 site (Nîmes) |
| Trial ID | NCT04462601 on ClinicalTrials.gov |
What this trial studies
This observational study investigates variations in serum translocation markers of the intestinal microbiota in patients diagnosed with Gougerot-Sjögren syndrome. The researchers aim to understand how changes in gut microbiota may influence gut permeability and potentially correlate with the disease activity of Sjögren's syndrome. By analyzing these biomarkers, the study seeks to uncover immunomodulatory effects that could provide insights into the management of the condition.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with primary Sjögren's syndrome who are members of a health insurance plan.
Not a fit: Patients with secondary Sjögren's syndrome or those participating in other interventional studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management strategies for patients with Sjögren's syndrome.
How similar studies have performed: While the specific approach of this study may be novel, similar studies investigating the gut microbiota's role in autoimmune diseases have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The patient must be a member or beneficiary of a health insurance plan * Patients with primary Sjögren's syndrome according to the AECG criteria Exclusion Criteria: * The subject is participating in a category I interventional study, or is in a period of exclusion determined by a previous study * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * Pregnant, parturient or breastfeeding patients * Patients with secondary Sjögren's syndrome
Where this trial is running
Nîmes
- CHU de Nimes — Nîmes, France (RECRUITING)
Study contacts
- Principal investigator: Radjiv Goulabchand — CHU Nimes
- Study coordinator: Radjiv Goulabchand
- Email: radjiv2001@hotmail.com
- Phone: +33 (0)7.61.39.30.82
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sjogren's Syndrome