Examining gut health, nutrition, and cognitive function in elderly small eaters
Official title: Loss of Autonomy in the Elderly: Relationships Between Gut Microbiota Diversity, Nutrition and Cognitive and Sensory-motor Disturbances in "Small Eaters" and "Non Small Eaters"
Run by Centre Hospitalier Universitaire Dijon · NCT05449119 · Data updated 2026-11-12
This study looks at how gut health, diet, and brain function are connected in older adults over 75 who eat very little after moving into care facilities.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 75 Years and up |
| Sex | All |
| Enrollment | 140 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | June 13, 2023 |
| Main results expected | June 2028 |
| Study ends | June 2028 |
| Registry record updated | August 15, 2024 |
| Trial ID | NCT05449119 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are elderly individuals over 75 years old residing in long-term care facilities who exhibit a loss of appetite.
✕Probably not a fit
Patients who are not affiliated with national health insurance or have specific gastrointestinal diseases like celiac disease or Crohn's disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the relationships between gut microbiota diversity, nutrition, and cognitive and sensory-motor disturbances in elderly individuals over 75 years old who are classified as 'small eaters' upon their admission to long-term care facilities. The research will involve fecal and blood sampling, along with the collection of nutritional, cognitive, and sensorimotor data, including BMI and muscle mass measurements. The aim is to understand how changes in diet and lifestyle affect gut health and cognitive function in this vulnerable population.
Why it matters
Potential benefit: If successful, this study could lead to improved nutritional strategies and interventions that enhance cognitive and sensory-motor functions in elderly individuals.
How similar studies have gone: While there is ongoing research into the effects of nutrition and gut microbiota on health in the elderly, this specific approach focusing on 'small eaters' is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Person who has given oral consent and has not objected to being included in the study, or if necessary, oral consent of an appointed legal representative. * A person over 75 years of age residing in an EHPAD who may be under guardianship or curatorship. * A person over 75 years of age with a loss of appetite (i.e. a small eater) residing in an EHPAD, who may be under guardianship or curatorship. Exclusion Criteria: * Person not affiliated to national health insurance * Elderly person with an infectious syndrome at the time of admission; * Elderly person with diarrhoea (infectious or not) at the time of admission; * Elderly person receiving recently prescribed antimicrobials at the time of admission (antibiotics or antifungals) * Elderly person with celiac disease and/or Crohn's disease. * Person under a measure of limited judicial protection
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Frédéric DALLE
- Email: frederic.dalle@chu-dijon.fr
- Phone: 0380295014
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.