Examining gene expression in oocytes from women with poor ovarian reserve
Official title: Elucidating the GREM1, HAS2 and PTGS2 Gene Expression as Oocytes Development Competency Markers Among Women With Poor Ovarian Reserve (POR) Following the in Vitro Maturation (IVM)
Run by National University of Malaysia · NCT06315777 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how certain genes in cells from women with poor ovarian reserve affect egg quality and fertility during in vitro fertilization.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 30 (estimated) |
| Sponsor | National University of Malaysia Academic / other |
| Locations | 1 site (Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur) |
| Trial ID | NCT06315777 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women undergoing IVF who meet the Bologna criteria for poor ovarian reserve.
✕Probably not a fit
Patients with male factor infertility or those who do not agree to participate may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the gene expression of GREM1, HAS2, and PTGS2 in cumulus cells from women with poor ovarian reserve (POR) undergoing in vitro maturation (IVM) and in vitro fertilization (IVF). It aims to compare the gene expression levels between normal and POR women to assess their impact on oocyte quality and subsequent fertility outcomes. The research will utilize discarded cumulus cells from IVF procedures to analyze gene expression through RNA extraction and RT-PCR techniques. The findings could provide insights into improving oocyte quality and live birth rates for women facing fertility challenges due to POR.
Why it matters
Potential benefit: If successful, this study could enhance fertility treatment outcomes for women with poor ovarian reserve by identifying key genetic markers associated with oocyte quality.
How similar studies have gone: While there is ongoing research in the field of oocyte quality and gene expression, this specific approach focusing on GREM1, HAS2, and PTGS2 in the context of IVM for POR women is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * women underwent IVF with normal and Poor ovarian reserve based on the Bologna criteria( anti-Müllerian hormone (AMH) below 0.5-1.1 ng/ml\]). Exclusion Criteria: * Male factor infertility (to reduce bias for embryo quality factor) * Not agree to participate.
Where it's running
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Advanced Reproductive Centre
Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Gene profiling of cumulus cells after CAPA‑IVM
This pilot will test whether gene patterns in cumulus cells collected after CAPA‑IVM can help predict egg and embryo quality for women with PCOS undergoing CAPA‑IVM.
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In vitro maturation of human eggs for fertility treatment
This study is testing a new way to help women with fertility issues by maturing their eggs in the lab with fewer hormones to see if it makes treatment easier and safer.
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IVM fresh embryo transfer (Saigon protocol) versus IVF with frozen embryo transfer for women with PCOS
This trial tests whether in vitro maturation with a fresh embryo transfer (the Saigon protocol) helps women with PCOS get pregnant as well as conventional IVF followed by a frozen embryo transfer.
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Evaluating Fertilo for In Vitro Maturation of Oocytes
This study is testing if a new treatment called Fertilo can help women aged 18-35 have more successful pregnancies during in vitro fertilization compared to a standard treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.