Examining gene expression in oocytes from women with poor ovarian reserve
Elucidating the GREM1, HAS2 and PTGS2 Gene Expression as Oocytes Development Competency Markers Among Women With Poor Ovarian Reserve (POR) Following the in Vitro Maturation (IVM)
This study is testing how certain genes in cells from women with poor ovarian reserve affect egg quality and fertility during in vitro fertilization.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | National University of Malaysia Academic / other |
| Locations | 1 site (Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur) |
| Trial ID | NCT06315777 on ClinicalTrials.gov |
What this trial studies
This study investigates the gene expression of GREM1, HAS2, and PTGS2 in cumulus cells from women with poor ovarian reserve (POR) undergoing in vitro maturation (IVM) and in vitro fertilization (IVF). It aims to compare the gene expression levels between normal and POR women to assess their impact on oocyte quality and subsequent fertility outcomes. The research will utilize discarded cumulus cells from IVF procedures to analyze gene expression through RNA extraction and RT-PCR techniques. The findings could provide insights into improving oocyte quality and live birth rates for women facing fertility challenges due to POR.
Who should consider this trial
Good fit: Ideal candidates for this study are women undergoing IVF who meet the Bologna criteria for poor ovarian reserve.
Not a fit: Patients with male factor infertility or those who do not agree to participate may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance fertility treatment outcomes for women with poor ovarian reserve by identifying key genetic markers associated with oocyte quality.
How similar studies have performed: While there is ongoing research in the field of oocyte quality and gene expression, this specific approach focusing on GREM1, HAS2, and PTGS2 in the context of IVM for POR women is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * women underwent IVF with normal and Poor ovarian reserve based on the Bologna criteria( anti-Müllerian hormone (AMH) below 0.5-1.1 ng/ml\]). Exclusion Criteria: * Male factor infertility (to reduce bias for embryo quality factor) * Not agree to participate.
Where this trial is running
Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
- Advanced Reproductive Centre — Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.