Examining fat tissue in people with obstructive sleep apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how obstructive sleep apnea (OSA) affects the cellular and molecular composition of adipose tissue compared to healthy individuals. Researchers will analyze adipose tissue samples to identify markers of cellular damage and understand the implications for cardiovascular disease risk. The study seeks to fill the knowledge gap regarding OSA-induced changes in fat tissue and their potential role in developing cardiometabolic disorders. By examining these changes, the study hopes to uncover pathways that could be targeted for therapeutic interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria

* BMI ≤40 kg/m2
* Not a current smoker or tobacco user
* Individuals with treated hypertension, prehypertension, and dyslipidemia will be allowed to participate in the study
* On no prescription medications other than those medications used to treat asthma, seasonal or environmental allergies (such as Cetirizine, Fexofenadine, Desloratadine, Loratadine, etc), depression, acid reflux (such as antacids or proton pump inhibitors), topical skin treatment medications or shampoos, contraceptive pills, or intrauterine devices. Other medications may be allowed at the discretion of the study staff.
* Not pregnant or breast feeding and not intending to become pregnant or breast feed
* Ability to provide written informed consent
* If a subject is on aspirin or any other anti-inflammatory medication but free of known vascular disease and depending on the indication, the study doctor may ask the subject to suspend aspirin or anti-inflammatory therapy for 7 days prior to participation in the study. In the event that the subject does not stop the aspirin or other anti-inflammatory medication, they will not be able to participate in the study because of the risk of bleeding during the fat biopsy.

Exclusion Criteria

* Vulnerable study population will be excluded
* Presence of chronic kidney disease (creatinine \>2.5 mg/dL) and/or active cancers
* Pregnancy
* Anemic (hemoglobin \<12 g/dL for men and \<11 g/dL for women)
* Smoking
* Use of chronic medications (statins, anti-inflammatory drugs, angiotensin II receptor blockers (ARBs) and/or angiotensin-converting enzyme (ACE) inhibitors)
* Blood or plasma donation during the past 2 months

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Virend Somers, MD., Ph.D — Mayo Clinic
• Study coordinator: Somers_CPL Lab
• Email: CPLOSA@mayo.edu
• Phone: 507-255-8794

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Assessing OSA risk in dental patients undergoing general anesthesia

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• Melatonin's effects on sleep and blood pressure in patients with obstructive sleep apnea

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• Effects of GLP-1 Agonists After Bariatric Surgery

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• Training to strengthen breathing muscles in people with obstructive sleep apnea

  This study is testing if a special breathing exercise program can help adults with obstructive sleep apnea feel less sleepy during the day and improve their breathing at night while using CPAP.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans · NCT06117579

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.