Examining endothelial cells in inflammatory conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize changes in gene expression in endothelial cells from patients with sepsis or those undergoing major abdominal surgery. Researchers will collect endothelial cells using a safe technique involving a metal guidewire inserted into an arm vein. The study will analyze RNA from these cells to identify molecular pathways that are differentially expressed during inflammatory conditions. Additionally, control samples will be obtained from healthy volunteers to compare the findings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Healthy volunteer

* Adult ≥ 18 years
* Able and willing to give consent

Surgical patients

* Adult ≥ 18 years
* Patients admitted to RSFT for planned major surgery

Critically ill patients

* Adult ≥ 18 years
* Emergency admission to ICU at RSFT
* Meets the sepsis 3.0 definition

Exclusion Criteria:

Healthy volunteer

* Not currently a patient within the hospital
* Absence of inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease and CKD.
* Not on immunomodulatory medications, such as corticosteroids
* History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)

Surgical patients

* Patients with restricted liberty, prisoners or under legal protection
* Anticipated prohibitively difficult venous cannulation
* Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, sepsis, diabetes with end organ damage, cardiovascular disease and CKD
* Currently prescribed immunomodulatory medication or immunocompromised
* Received chemotherapy within 2 weeks of predicted sampling
* Receiving vasopressor support prior to surgery
* History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)

Critically ill patients

* Patients with restricted liberty, prisoners or under legal protection• Anticipated prohibitively difficult venous cannulation
* Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes with end organ damage, cardiovascular disease and CKD.
* Currently prescribed immunomodulatory medication or immunocompromised
* Received chemotherapy within 2 weeks of predicted sampling.
* History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)

Where it's running

• Royal Surrey NHS Foundation Trust
  Guildford, Surrey, United Kingdom Recruiting

Study contacts

• Study coordinator: Ben Creagh-Brown, BM, PhD
• Email: bencb@nhs.net
• Phone: +44 (0)1483 688 660

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.