Examining cardiovascular disease diagnosis and prognosis
Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
University Hospitals, Leicester · NCT04388943
This study is trying to see how different heart diseases affect patients compared to healthy people, by looking at their health details and samples to improve diagnosis and predict future health issues.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 9500 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | University Hospitals, Leicester (other) |
| Locations | 1 site (Leicester) |
| Trial ID | NCT04388943 on ClinicalTrials.gov |
What this trial studies
This project investigates the diagnosis and prognosis of patients with various cardiovascular diseases, comparing their characteristics to healthy controls from the community. It includes both inpatients and outpatients aged 18-90 with conditions such as coronary artery disease, heart failure, and hypertension. The study will collect clinical details, along with blood and urine samples, to analyze proteins, chemicals, and genetic biomarkers, aiming to enhance diagnostic accuracy and predict future clinical events. The findings may lead to improved understanding of the pathological mechanisms involved in cardiovascular diseases.
Who should consider this trial
Good fit: Ideal candidates include inpatients and outpatients aged 18-90 with cardiovascular diseases or healthy volunteers from the community.
Not a fit: Patients unable to provide consent or those with severe non-cardiovascular comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and better predictions of outcomes for patients with cardiovascular diseases.
How similar studies have performed: Other studies have shown success in using biomarker analysis for cardiovascular diseases, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All outpatients and inpatients with cardiovascular disease, of either gender * Aged 18-90 years old * Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain * Healthy volunteers * Aged 18-90 years old * From the community without cardiovascular or other diseases Exclusion Criteria: * Any patient who is unable to give consent * Any patient with non-cardiovascular comorbidity likely to cause death within 6 months * Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material
Where this trial is running
Leicester
- University Hospitals Leicester — Leicester, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Nilesh J Samani, Professor — NIHR Leicester Biomedical Research Centre
- Study coordinator: Emma P Beeston
- Email: emma.beeston@uhl-tr.nhs.uk
- Phone: 0116 204 4738
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiovascular Diseases, Cardiovascular Risk Factor