Examining cardiovascular disease diagnosis and prognosis
Official title: Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
Run by University Hospitals, Leicester · NCT04388943 · Data updated 2026-11-12
This study is trying to see how different heart diseases affect patients compared to healthy people, by looking at their health details and samples to improve diagnosis and predict future health issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 9500 (estimated) |
| Sponsor | University Hospitals, Leicester Academic / other |
| Locations | 1 site (Leicester) |
| Status | Recruiting |
| Started | June 17, 2010 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | June 11, 2026 |
| Trial ID | NCT04388943 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include inpatients and outpatients aged 18-90 with cardiovascular diseases or healthy volunteers from the community.
✕Probably not a fit
Patients unable to provide consent or those with severe non-cardiovascular comorbidities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project investigates the diagnosis and prognosis of patients with various cardiovascular diseases, comparing their characteristics to healthy controls from the community. It includes both inpatients and outpatients aged 18-90 with conditions such as coronary artery disease, heart failure, and hypertension. The study will collect clinical details, along with blood and urine samples, to analyze proteins, chemicals, and genetic biomarkers, aiming to enhance diagnostic accuracy and predict future clinical events. The findings may lead to improved understanding of the pathological mechanisms involved in cardiovascular diseases.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and better predictions of outcomes for patients with cardiovascular diseases.
How similar studies have gone: Other studies have shown success in using biomarker analysis for cardiovascular diseases, indicating a promising approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All outpatients and inpatients with cardiovascular disease, of either gender * Aged 18-90 years old * Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain * Healthy volunteers * Aged 18-90 years old * From the community without cardiovascular or other diseases Exclusion Criteria: * Any patient who is unable to give consent * Any patient with non-cardiovascular comorbidity likely to cause death within 6 months * Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material
Where it's running
-
University Hospitals Leicester
Leicester, United Kingdom Recruiting
Study contacts
- Principal investigator: Nilesh J Samani, Professor — NIHR Leicester Biomedical Research Centre
- Study coordinator: Emma P Beeston
- Email: emma.beeston@uhl-tr.nhs.uk
- Phone: 0116 204 4738
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.