Examining brain metabolites and postoperative delirium in elderly patients undergoing oral surgery
Correlation of Perioperative Brain Metabolites With Postoperative Delirium in Elderly Oral Craniomaxillofacial Surgery Patients
This study is trying to see if certain brain chemicals in older patients having oral surgery can help us understand why some of them experience confusion after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 46 (estimated) |
| Ages | 65 Years to 90 Years |
| Sex | All |
| Sponsor | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT05694091 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between perioperative brain metabolites and the occurrence of postoperative delirium (POD) in elderly patients aged 65 to 90 undergoing elective oral craniomaxillofacial surgery. The study aims to collect clinical data, blood gas data, and samples for Magnetic Resonance Spectroscopy (MRS) to better understand the factors contributing to POD. Given the high incidence of POD in this demographic, the findings could provide insights into improving postoperative cognitive outcomes. The research is conducted at Shanghai Ninth People's Hospital, focusing on a critical aspect of elderly patient care.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 65 to 90 who are undergoing elective oral craniomaxillofacial surgery under general anesthesia.
Not a fit: Patients with certain medical devices, left-handed individuals, those with claustrophobia, or significant communication barriers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing postoperative delirium in elderly patients, enhancing their recovery and quality of life.
How similar studies have performed: While the specific approach of correlating brain metabolites with POD in this surgical context may be novel, similar studies have indicated the importance of monitoring cognitive outcomes in elderly surgical patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The ASA grade of the subject is Ⅰ - Ⅲ; * 65-90 years old; * Oral craniomaxillofacial surgery under combined general anesthesia Exclusion Criteria: * The following medical devices have been installed in the body or are to be installed or implanted in the hospital: various cardiac pacemakers; Metal implants (non titanium), ferromagnetic vascular clips in the body * The patient is left-handed; * Patients with claustrophobia; * People with vision and hearing impairment, illiterate or difficult to communicate; * The operation plan includes patients with tracheotomy or postoperative catheterization; * Refusing to sign the clinical trial consent form.
Where this trial is running
Shanghai, Shanghai
- Shanghai 9Th Hospital — Shanghai, Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Ren Zhou, PhD
- Email: zhouren77@126.com
- Phone: 15121007303
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.