Examining brain connectivity in patients with hereditary retinal dystrophies using MRI
Official title: VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT04648124 · Data updated 2026-11-12
This study is trying to see how brain connections related to vision work in people with hereditary retinal dystrophies using MRI scans.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris, PARIS) |
| Status | Recruiting |
| Started | January 4, 2021 |
| Main results expected | January 2026 |
| Study ends | July 2028 |
| Registry record updated | January 5, 2026 |
| Trial ID | NCT04648124 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 with a clinical diagnosis of hereditary retinal dystrophy or maculopathy, who are not undergoing certain treatments like retinal implants in the next six months.
✕Probably not a fit
Patients with legal protection measures, pregnant or breastfeeding women, those with contraindications to MRI, or recent eye surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study involves a cohort of approximately 300 patients with hereditary retinal dystrophy who are followed annually at the Rothschild Foundation A Hospital. Patients will be informed about the study prior to their ophthalmology consultation, and if they consent, resting state functional MRI (rMRI) will be scheduled on the same day to assess visual brain networks. The study aims to gather data on brain connectivity related to vision in these patients, potentially enhancing understanding of their condition.
Why it matters
Potential benefit: If successful, this study could provide insights into the brain's visual processing in patients with hereditary retinal dystrophies, potentially guiding future treatments.
How similar studies have gone: While this approach is relatively novel, similar studies using MRI to assess brain connectivity in visual disorders have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient over 18 years old * Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique * Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman * Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker). * Other additional ocular pathology that can significantly affect vision * Recent eye surgery less than 3 months old
Where it's running
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Fondation Adolphe de Rothschild
Paris, Paris, France Recruiting
Study contacts
- Principal investigator: Augustin LECLER — Fondation Ophtalmologique A. de Rothschild
- Study coordinator: Amélie YAVCHITZ
- Email: ayavchitz@for.paris
- Phone: 0148036454
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.