Examining brain characteristics related to cognitive issues after surgery in older patients
Correlation Between Postoperative Cognitive-related Adverse Reactions and Brain Metabolomic Characteristics in Elderly Patients
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · NCT05555693
This study is trying to see if there are specific brain changes in older patients that might explain why some have trouble thinking clearly after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (other) |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT05555693 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between postoperative cognitive dysfunction (POCD) and brain metabolomic characteristics in elderly patients. It focuses on understanding how cognitive difficulties following anesthesia and surgery may be linked to underlying brain metabolism and neuropsychiatric conditions. Researchers will collect clinical data, EEG readings, brain metabolomic characteristics using Magnetic Resonance Spectroscopy, as well as blood gas data and blood samples from participants. The goal is to identify potential biomarkers and mechanisms associated with POCD in this vulnerable population.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 65 years or older who are undergoing surgery at the participating hospital.
Not a fit: Patients with a history of preoperative psychosis, diagnosed Alzheimer's disease, or those with significant preoperative cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive dysfunction in elderly patients after surgery.
How similar studies have performed: While there is ongoing research into POCD and its connections to neuropsychiatric diseases, this specific approach focusing on brain metabolomic characteristics is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 65 years or older . * Complete the operation in our hospital * ASA classification I-II level * Agree to participate in this research and agree to sign an informed consent form Exclusion Criteria: * History of preoperative psychosis and psychotropic drug use * The subject is diagnosed with AD; * Abnormal preoperative mental scale assessment * Have a history of emergency rescue during the perioperative period * metal implants * Postoperative immobilization patients
Where this trial is running
Shanghai, Shanghai Municipality
- Shanghai 9Th Hospital — Shanghai, Shanghai Municipality, China (RECRUITING)
Study contacts
- Study coordinator: Ren Zhou, PhD
- Email: zhouren77@126.com
- Phone: 15121007303
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: POCD - Postoperative Cognitive Dysfunction