Examining brain characteristics related to cognitive issues after surgery in older patients
Official title: Correlation Between Postoperative Cognitive-related Adverse Reactions and Brain Metabolomic Characteristics in Elderly Patients
Run by Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · NCT05555693 · Data updated 2026-11-12
This study is trying to see if there are specific brain changes in older patients that might explain why some have trouble thinking clearly after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | July 27, 2022 |
| Main results expected | January 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | September 27, 2022 |
| Trial ID | NCT05555693 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are elderly patients aged 65 years or older who are undergoing surgery at the participating hospital.
✕Probably not a fit
Patients with a history of preoperative psychosis, diagnosed Alzheimer's disease, or those with significant preoperative cognitive impairments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the relationship between postoperative cognitive dysfunction (POCD) and brain metabolomic characteristics in elderly patients. It focuses on understanding how cognitive difficulties following anesthesia and surgery may be linked to underlying brain metabolism and neuropsychiatric conditions. Researchers will collect clinical data, EEG readings, brain metabolomic characteristics using Magnetic Resonance Spectroscopy, as well as blood gas data and blood samples from participants. The goal is to identify potential biomarkers and mechanisms associated with POCD in this vulnerable population.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive dysfunction in elderly patients after surgery.
How similar studies have gone: While there is ongoing research into POCD and its connections to neuropsychiatric diseases, this specific approach focusing on brain metabolomic characteristics is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 65 years or older . * Complete the operation in our hospital * ASA classification I-II level * Agree to participate in this research and agree to sign an informed consent form Exclusion Criteria: * History of preoperative psychosis and psychotropic drug use * The subject is diagnosed with AD; * Abnormal preoperative mental scale assessment * Have a history of emergency rescue during the perioperative period * metal implants * Postoperative immobilization patients
Where it's running
-
Shanghai 9Th Hospital
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Ren Zhou, PhD
- Email: zhouren77@126.com
- Phone: 15121007303
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How anesthesia type affects thinking after bariatric sleeve surgery
This observational study tests whether intravenous anesthesia or inhalational anesthesia leads to different cognitive outcomes after sleeve gastrectomy in adults with obesity.
-
Zemetostat plus Anlotinib for SWI/SNF-deficient Head and Neck Soft Tissue Sarcoma
This trial tests whether zemetostat plus anlotinib can help people with recurrent or metastatic head-and-neck soft tissue sarcoma that has SWI/SNF complex deficiency after standard therapy fails.
-
Iparomlimab and Tuvonralimab With Cetuximab Before Surgery in Resectable Oral Cancer
In this phase 2 study, patients with locally advanced, resectable oral squamous cell carcinoma will receive a combination of iparomlimab, tuvonralimab, and cetuximab before surgery to see if the treatment is safe and can shrink tumors.
-
Abiraterone with dalpiciclib in AR-positive, HER-2 negative salivary gland cancer
This phase 2 trial tests whether combining abiraterone and dalpiciclib helps people with AR-positive, HER-2 negative salivary gland cancer that has come back or spread.
-
Paclitaxel polymeric micelles with carboplatin in adults with recurrent/metastatic head and neck cancer
This study tests a paclitaxel micelle formulation combined with carboplatin in adults with head and neck cancer whose disease has progressed after prior therapy.
-
Camrelizumab with Famitinib for rare head and neck cancers
This trial tests whether combining camrelizumab with famitinib can help adults with unresectable or metastatic soft tissue sarcoma, malignant melanoma, adenoid cystic carcinoma, or certain salivary gland cancers who have not tried a PD-1 inhibitor before.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.