Examining brain activity during swallowing in patients with Lateral Medullary Syndrome
Cortical Activation and Functional Connectivity Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome
This study is trying to see how swallowing affects brain activity in people with Lateral Medullary Syndrome compared to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | The First Affiliated Hospital of Zhengzhou University Academic / other |
| Locations | 1 site (Zhengzhou, Henan) |
| Trial ID | NCT06208020 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate changes in cortical activation and functional connectivity during swallowing in patients with dysphagia caused by Lateral Medullary Syndrome (LMS). Using functional near-infrared spectroscopy (fNIRS), the study will compare the brain activity of LMS patients to that of healthy subjects while they perform swallowing tasks. The primary focus is to identify differences in brain function related to swallowing, which may provide insights into the neurological underpinnings of dysphagia in this patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are right-handed adults aged 18-80 who have experienced their first ischemic stroke confirmed as Lateral Medullary Syndrome and have dysphagia.
Not a fit: Patients with other central nervous system diseases or serious physical or mental disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of dysphagia in LMS patients, potentially leading to improved treatment strategies.
How similar studies have performed: While there is limited information on similar studies, the use of fNIRS in assessing cortical function during swallowing is a relatively novel approach in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The first ischemic stroke was confirmed by head MRI as LMS; * 18-80 years old, right-handed; * Dysphagia was confirmed by video fluoroscopic swallow study(VFSS); * Conscious enough to cooperate with fNIRS testing; * No previous neurological or mental illness. Exclusion Criteria: * Other central nervous system diseases (Parkinson's disease, Alzheimer's disease, intracranial tumors, etc.); * Other diseases causing dysphagia (tumors of the esophagus, larynx, nasopharynx, etc.); * Serious physical diseases (cancer, fracture, etc.); * Other mental disorders (mania, schizophrenia, etc.); * Unconscious, unable to cooperate with the examination
Where this trial is running
Zhengzhou, Henan
- The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China (Recruiting)
Study contacts
- Study coordinator: Yi Li, Master
- Email: muziyi3696085@163.com
- Phone: +8618810838848
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.